Additionally, the expression of Bcl-2 was also enhanced in all the thyroid cancer cells and miR-15 ectopic expression could cause suppression of the Bcl-2 expression in MDA-T35 cells.
Nevertheless, overexpression of Bcl-2 may result in "oncogene addiction" of the cancer cell, which can be exploited by using BH3-domain inhibitors alone or in combination with other agents, including conventional chemotherapeutics (such as doxorubicin) or novel targeted therapies (such as the proteasome inhibitor bortezomib), for the treatment of aggressive thyroid cancer, including the medullary and anaplastic types.