Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE Immunohistochemistry showed the positive expression of NIS and TSHR in thyroid cancer group. 30058701 2018
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE The mRNA expression levels of CSC- (CD133 and CD44) and ES-related genes (Oct4 and Nanog) were higher in TC tissue than in normal thyroid tissue, whereas the mRNA expression levels of thyroid-specific genes (Tg, TSHR, and TTF1) were higher in normal thyroid tissue than in TC tissue. 30160089 2018
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE These studies evaluating the etiological roles of these factors in linking breast and thyroid cancer might also improve our understanding and identify new therapeutic approaches, such as sodium/iodide symporter-mediated radioiodine therapy and thyroid-stimulating hormone receptor antagonists, for breast cancer. 29976206 2018
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE Our meta-analysis suggests that TSHR-mRNA might be a potential biomarker to complete present diagnostic methods for early and precision diagnosis of thyroid cancer. 28036261 2017
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE This review examines the evidence for TSHR signaling as an oncogenic pathway and assesses the evidence for ongoing TSHR expression in thyroid cancer metastases. 28351942 2017
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE In addition, the prognostic value of TSHR in thyroid cancer was analyzed. 29344196 2017
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE Here, we present an example of the construction of silicon dioxide nanoparticles with thyroid-stimulating-hormone receptor-targeting ligand that can specifically target the thyroid cancer. 28860762 2017
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE Different expression of TSH receptor and NIS genes in thyroid cancer: role of epigenetics. 24353283 2014
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 GeneticVariation disease BEFREE The promoter region of TSHR gene was found to be methylated in 25 % (15 of 60) of the thyroid cancer patients. 24927793 2014
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE TSH receptor mRNA reverse transcription-polymerase chain reaction, the Veracyte and Asuragen commercial methods, and the noncommercial use of BRAF, RAS, RET/PTC, and PAX8/PPARγ testing have promising roles in the diagnosis and treatment of patients with nodular thyroid disease and thyroid cancer. 22984796 2013
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE Preoperative thyrotropin receptor messenger RNA was measured in 9 patients: 3 of 4 with thyroid cancer had elevated levels and 3 of 5 with goiters undetectable. 22244412 2012
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE In addition, there was no correlation between NIS and TSHR in thyroid cancer, which may explain why, even after TSH stimulation, 10-20% of these malignant tumors are unable to concentrate enough radioiodine for effective therapy. 21989446 2012
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE TSHR mRNA also represents a new blood test to aid assessment of disease status in thyroid cancer follow-up. 20881771 2010
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE Recently, the value of thyroid-stimulating hormone receptor(TSHR) mRNA as a molecular marker in diagnosis of thyroid cancer has been greatly explored. 20429628 2010
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE Circulating thyroid cancer cells detected by peripheral blood thyroid-stimulating hormone receptor (TSHR) mRNA have demonstrated usefulness for thyroid cancer diagnosis and long-term surveillance. 19958935 2009
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 GeneticVariation disease BEFREE As such, this article addresses the following aspects of intragenic mutations in thyroid cancer: thyroid stimulating hormone receptor and guanine-nucleotide-binding proteins of the stimulatory family mutations in hyperfunctioning tumors; mutations in RAS and other genes and aneuploidy; PAX8-PPARgamma rearrangements; BRAF mutations; mutations in oxidative phosphorylation and Krebs cycle genes in Hürthle cell tumors; mutations in succinate dehydrogenase genes in medullary carcinoma and C-cell hyperplasia; and mutations in TP53 and other genes in poorly differentiated and anaplastic carcinomas. 18502330 2008
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE Furthermore, monoclonal antibodies such as 5C9 may well provide the basis of new drugs to control TSHR activity including applications in thyroid cancer and Graves' ophthalmopathy. 18631002 2008
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE As disturbed thyrotropin receptor signaling plays a central role in hot thyroid nodules, the identification of effective low-molecular-weight thyrotropin receptor ligands, such as thyrotropin receptor agonists, inverse agonists and antagonists has a pharmacologic potential in the diagnosis and treatment of thyroid cancer, Graves' disease and hot thyroid nodules, respectively. 17940470 2007
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE Methylation of thyroid-specific genes, such as those for sodium/iodide symporter and thyroid-stimulating hormone receptor, is also common in thyroid cancer. 16946009 2007
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 GeneticVariation disease BEFREE It remains unclear whether TSHR alterations in thyroid cancers play a role in the onset or they appear as a consequence of genetic instability during evolution, but the presence of functional TSHR is exploited in therapy. 17891229 2007
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE Among these, thyroglobulin, and more recently thyroid-stimulating hormone receptor mRNAs' provide high diagnostic sensitivity and specificity for thyroid cancer detection. 17940468 2007
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE Thyroid-stimulating hormone receptor messenger ribonucleic acid measurement in blood as a marker for circulating thyroid cancer cells and its role in the preoperative diagnosis of thyroid cancer. 17118994 2007
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE Qualitative analysis of baseline and stimulated TG, NIS and PDS mRNA showed high sensitivity but low specificity in the prediction of thyroid cancer recurrence or metastases (accuracy under THST = 51%, 43% and 54%, respectively), whereas TPO and TSHR mRNA assays had higher specificity but low sensitivity, with accuracy under THST of 67% and 61%, respectively, that improved when these tests were combined. 15170676 2004
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE Detection of thyrotropin-receptor messenger ribonucleic acid (mRNA) and thyroglobulin mRNA transcripts in peripheral blood of patients with thyroid disease: sensitive and specific markers for thyroid cancer. 15292293 2004
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE We have established that thyroid hormone receptor beta1 (TRbeta1) is associated with the loss of TSHR gene expression in an anaplastic human thyroid cancer cell line, ARO. 12429043 2002