Gene: NKX2-1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7080
Gene Symbol: NKX2-1
NKX2-1 		0.060 AlteredExpression disease BEFREE The majority of mucinous adenocarcinomas expressed thyroid transcription factor 1, Napsin A, Villin and Cam5.2 proteins. 29375717 2018
Entrez Id: 7080
Gene Symbol: NKX2-1
NKX2-1 		0.060 GeneticVariation disease BEFREE 86% of GNAS-mutated non-mucinous adenocarcinomas (6/7) were positive for TTF-1 immunohistochemistry, while only 25% of GNAS-mutated IMAs (1/4) were positive for TTF-1. 28776576 2017
Entrez Id: 7080
Gene Symbol: NKX2-1
NKX2-1 		0.060 GeneticVariation disease BEFREE KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung. 26829311 2016
Entrez Id: 7080
Gene Symbol: NKX2-1
NKX2-1 		0.060 GeneticVariation disease BEFREE Here, we show that haploinsufficiency of Nkx2-1 in combination with oncogenic Kras(G12D), but not with oncogenic EGFR(L858R), caused pulmonary tumors in transgenic mice that were phenotypically similar to human mucinous adenocarcinomas. 23143308 2012
Entrez Id: 7080
Gene Symbol: NKX2-1
NKX2-1 		0.060 Biomarker disease BEFREE TTF-1 was detectable in 4/99 (4%) squamous cell carcinomas, 169/176 (96%) solitary adenocarcinomas, 34/34 (100%) multifocal adenocarcinomas, 1/1 (100%) signet ring cell carcinoma, 16/20 (80%) mucinous adenocarcinomas, 23/23 (100%) nonmucinous bronchioloalveolar carcinomas, 19/36 (53%) small cell carcinomas, and 39/44 (89%) sclerosing hemangioma. 15084379 2004
Entrez Id: 7080
Gene Symbol: NKX2-1
NKX2-1 		0.060 Biomarker disease BEFREE Conversely, the two signet-ring cell-type MCs were stained with TTF-1, CK7, and MUC5AC but were negative for CDX-2, MUC2, and CK20. 15087663 2004