Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7791
Gene Symbol: ZYX
ZYX
0.020 Biomarker disease BEFREE QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells. 21920000 2012
Entrez Id: 7791
Gene Symbol: ZYX
ZYX
0.020 Biomarker disease BEFREE Misregulation of nuclear functions of zyxin appears to be associated with pathogenic effects and diseases, such as prostate cancer and non-small-cell lung cancer. 30657586 2019
Entrez Id: 440590
Gene Symbol: ZYG11A
ZYG11A
0.010 Biomarker disease BEFREE Our data suggest that ZYG11A may serve as a novel oncogene promoting tumorigenicity of NSCLC cells by inducing cell cycle alterations and increasing CCNE1 expression. 26771237 2016
Entrez Id: 57643
Gene Symbol: ZSWIM5
ZSWIM5
0.010 AlteredExpression disease BEFREE ZSWIM5-negative expression was significantly related to TNM stage (<i>P</i><0.001), lymph node metastasis (<i>P</i>=0.002), and poor prognosis (<i>P</i><0.001) of NSCLC patients. 30233241 2018
Entrez Id: 8882
Gene Symbol: ZPR1
ZPR1
0.010 Biomarker disease BEFREE ZNF259 depletion is correlated with the development of non-small cell lung cancer (NSCLC) and serves as a predictor of adverse clinical outcome in NSCLC patients. 29276408 2017
Entrez Id: 223082
Gene Symbol: ZNRF2
ZNRF2
0.010 Biomarker disease BEFREE In vitro, overexpression of ZNRF2 increased NSCLC cell growth and suppressed apoptotic cell death in the presence of Fluorouracil, while depletion of ZNRF2 decreased NSCLC cell growth and increased apoptotic cell death in the presence of fluorouracil. 27775798 2016
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 AlteredExpression disease BEFREE Rab11a overexpression promoted proliferation, colony formation, invasion and migration with upregulation of cyclin D1, cyclin E, and downregulation of p27 in NSCLC cell lines. 28468127 2017
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 Biomarker disease BEFREE They demonstrate that cytoplasmic p27 binds and inhibits the small GTPase RhoB and thereby relieves a selection pressure for RhoB loss that is frequently observed in NSCLC. 30549261 2019
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 Biomarker disease BEFREE The p27 positivity in the biopsy specimens of advanced NSCLC appears to be a useful prognostic marker. 10598929 1999
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 Biomarker disease BEFREE Deregulation of p27 and cyclin D1/D3 control over mitosis is associated with unfavorable prognosis in non-small cell lung cancer, as determined in 405 operated patients. 20631637 2010
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 AlteredExpression disease BEFREE These findings suggest that alteration in p27 levels plays an important role in lung tumor progression and that p27 levels may have independent prognostic significance in non-small cell lung cancer. 9973218 1999
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 Biomarker disease BEFREE miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer. 25151966 2015
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 AlteredExpression disease BEFREE Further results revealed that TRPV3 inhibition decreased expressions of p-CaMKII, CyclinA, CyclinD1, CyclinE, and increased P27 level; (4) CONCLUSIONS: Our findings demonstrate that TRPV3 was overexpressed in NSCLC and correlated with lung cancer progression. 27023518 2016
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 AlteredExpression disease BEFREE Collectively, our findings identified miR‑221‑3p as a novel regulator of NSCLC cell growth via modulating the expression of p27. 31180541 2019
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 AlteredExpression disease BEFREE To further elucidate the role of the molecule in tumor growth regulation, we evaluated p27 expression in a series of non-small cell lung carcinomas (NSCLCs), and examined its relation with histology, kinetic parameters, ploidy, and overall survival. 11474135 2001
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 AlteredExpression disease BEFREE In agreement with these results, cytoplasmic p27 is preferentially observed in primary NSCLCs with activated AKT and predicts poor survival. 26053093 2015
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 Biomarker disease BEFREE In addition, confirmation of the involvement of the proteasome-mediated proteolysis in p27 degradation should stimulate new strategies of nonsurgical treatments of non-small cell lung cancer. 9270000 1997
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 Biomarker disease BEFREE Here, we investigated how cytoplasmic p27 participates in the development of non-small cell lung carcinomas. 30206932 2019
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 Biomarker disease BEFREE SIRT1 is a key regulator of p27 protein levels and SIRT1 inhibition is a viable strategy for NSCLC therapy by means of p27 reactivation. 25143434 2015
Entrez Id: 10534
Gene Symbol: ZNRD2
ZNRD2
0.100 Biomarker disease BEFREE Overexpression of SIRT2 promoted Skp2 deacetylation and degradation, resulting in increases in p27 and suppression of NSCLC cell growth, whereas knockdown of Skp2 inhibited Skp2 deacetylation and degradation, resulting in decreases in p27 and increases in NSCLC cell growth. 26942878 2016
Entrez Id: 155061
Gene Symbol: ZNF746
ZNF746
0.010 Biomarker disease BEFREE Overall, our findings suggest that inhibition of ZNF746 suppresses the invasion and EMT molecules in H460 NSCLC cells and ZNF746 may be an important target molecule in lung tumorigenesis. 24145959 2014
Entrez Id: 58491
Gene Symbol: ZNF71
ZNF71
0.010 AlteredExpression disease BEFREE The protein expression of ZNF71 quantified with AQUA scores produced robust patient stratification in separate training (P = 0.021) and validation (P = 0.047) NSCLC cohorts. 29861409 2018
Entrez Id: 80139
Gene Symbol: ZNF703
ZNF703
0.010 Biomarker disease BEFREE Our data show that ZNF703 may contribute to tumor development in NSCLC by activating the Akt/mTOR pathway. 27650486 2016
Entrez Id: 342926
Gene Symbol: ZNF677
ZNF677
0.010 PosttranslationalModification disease BEFREE We identified methylation as main mechanism for ZNF677 downregulation in NSCLC cells and we observed tumor-specific ZNF677 methylation in NSCLC patients (p < 0.0001). 25504438 2015
Entrez Id: 79759
Gene Symbol: ZNF668
ZNF668
0.010 AlteredExpression disease BEFREE The results of the present study suggest that ZNF668 is downregulated in human NSCLC. 29556277 2018