Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1308
Gene Symbol: COL17A1
0.010 AlteredExpression disease BEFREE Analysis of publicly available tumor expression data revealed that NSCLC and skin co-express BP180, BP230 and type VII collagen. 31449902 2020
Entrez Id: 574503
Gene Symbol: MIR501
0.010 Biomarker disease BEFREE Collectively, these results indicate that miR-501-3p acts as a tumor suppressor in NSCLC by directly targeting RAP1A mRNA and may serve as a theranostic biomarker for patients with NSCLC. 31805277 2020
Entrez Id: 10112
Gene Symbol: KIF20A
0.010 Biomarker disease BEFREE These results suggest that KIF20A may act as a putative oncogene and a potential therapeutic target in NSCLC. 31557334 2020
Entrez Id: 498
Gene Symbol: ATP5F1A
0.010 Biomarker disease BEFREE Receiver operating characteristic curve analysis show that ORM1 and total ORM have excellent diagnostic efficacies, with area under the curve of 0.862 and 0.920, respectively, which significantly distinguished very early-NSCLC (IA) from healthy samples. 31482685 2020
Entrez Id: 7128
Gene Symbol: TNFAIP3
0.010 Biomarker disease BEFREE In conclusion, miR-605-5p promotes invasion and proliferation by targeting TNFAIP3 in NSCLC, and may provide possible biomarkers for NSCLC therapy. 31452243 2020
Entrez Id: 100126311
Gene Symbol: MIR147B
0.010 Biomarker disease BEFREE An inverse correlation between miR-147b and RPS15A was evidenced in NSCLC specimens. 31665807 2020
Entrez Id: 63941
Gene Symbol: NECAB3
0.010 Biomarker disease BEFREE GNAS-AS1/miR-4319/NECAB3 axis promotes tumor progression of NSCLC by altering macrophage polarization. 31267263 2020
Entrez Id: 64284
Gene Symbol: RAB17
0.010 Biomarker disease BEFREE The functional assays showed that knockdown of Rab17 could promote tumorigenic properties of NSCLC cells in vitro and in vivo, including enhanced cell proliferation, colony formation, invasion and migration, angiogenesis and tumor xenograft growth, and suppressed apoptosis. 31841274 2020
Entrez Id: 401247
Gene Symbol: LINC00243
0.010 AlteredExpression disease BEFREE LINC00243 expression increased in human NSCLC tissues and associated with poor prognosis of NSCLC patients. 31595421 2020
Entrez Id: 8848
Gene Symbol: TSC22D1
0.010 Biomarker disease BEFREE The lower number of mutations, enabled us to identify TSC22D1 as a potential driver gene in NSCLC. 31745979 2019
Entrez Id: 5367
Gene Symbol: PMCH
0.010 AlteredExpression disease BEFREE We studied the effects of MEK inhibitors (MEK-I) on PD-L1 and MCH-I protein expression and cytokine production in vitro in NSCLC cell lines and in PBMCs from healthy donors and NSCLC patients, the efficacy of combining MEK-I with anti-PD-L1 antibody in ex-vivo human spheroid cultures obtained from fresh biopsies from NSCLC patients in terms of cell growth arrest, cytokine production and T-cell activation by flow cytometry. 31196138 2019
Entrez Id: 6464
Gene Symbol: SHC1
0.010 Biomarker disease BEFREE Our current study found that EGFR activation in NSCLC cells releases SHC-binging protein 1 (SHCBP1) from SHC adaptor protein 1 (SHC1), which subsequently translocates into the nucleus and directly promotes the transactivating activity of β-catenin, consequently resulting in development of NSCLC cell stemness and malignant progression. 30177836 2019
Entrez Id: 10752
Gene Symbol: CHL1
0.010 AlteredExpression disease BEFREE CHL1 was expressed in NSCLC patients and was significantly overexpressed in lung adenocarcinomas and squamous cell carcinomas compared to neuroendocrine and large cell carcinomas of the lung (p < 0.001). 31372722 2019
Entrez Id: 100302137
Gene Symbol: MIR1914
0.010 AlteredExpression disease BEFREE However, the biomechanism through which METTL3 regulates MALAT1-miR-1914-3p-YAP axis activity to induce NSCLC drug resistance and metastasis is not very clear. 31818312 2019
Entrez Id: 4049
Gene Symbol: LTA
0.010 Biomarker disease BEFREE A dampened effector response (IFNα2, IFNγ, MIP1α, TNFα and TNFβ) was detected in NSCLC PE, but not mesothelioma or benign PE. 31741710 2019
Entrez Id: 5538
Gene Symbol: PPT1
0.010 Biomarker disease BEFREE Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer. 30876460 2019
Entrez Id: 7360
Gene Symbol: UGP2
0.010 AlteredExpression disease BEFREE Our data reveal that lncRNA-SVUGP2 is under-expressed in NSCLC cells and the reduced expression of lncRNA-SVUGP2 may enhance the development and process of NSCLC by interacting with EZH2 and activating Wnt/β-catenin pathway. 31401873 2019
Entrez Id: 8436
Gene Symbol: CAVIN2
0.010 Biomarker disease BEFREE SDPR-AS may serve as a prospective target for NSCLC diagnosis and therapy. 31352804 2019
Entrez Id: 203190
Gene Symbol: LGI3
0.010 GeneticVariation disease BEFREE Analysis of the somatic mutations of the LGI3 gene in NSCLC revealed that the amino acid residues altered in NSCLC included two single nucleotide polymorphism sites and three phylogenetically coevolved amino acid residues. 31452819 2019
Entrez Id: 55127
Gene Symbol: HEATR1
0.010 AlteredExpression disease BEFREE <b>Results:</b> HEATR1 levels were significantly higher in NSCLC tumor tissues compared to normal adjacent lung tissues (<i>P</i><0.001). 31190896 2019
Entrez Id: 79940
Gene Symbol: LINC00472
0.010 AlteredExpression disease BEFREE LINC00472 and KLLN were found to exhibit low levels, while miR-149-3p and miR-4270 were highly expressed in NSCLC. 31382188 2019
Entrez Id: 57192
Gene Symbol: MCOLN1
0.010 Biomarker disease BEFREE It was found that MCOLN1 expression was significantly decreased in human NSCLC tissues compared with normal lung tissues while more MCOLN1 in stage III-IV was shown than stage I-II, indicating that MCOLN1 increased along with the progression of NSCLC. 31576167 2019
Entrez Id: 53616
Gene Symbol: ADAM22
0.010 AlteredExpression disease BEFREE The results demonstrated that the expression levels of LGI3 and its receptor a disintegrin and metalloproteinase domain-containing protein 22 were significantly decreased in NSCLC tissues. 31452819 2019
Entrez Id: 9530
Gene Symbol: BAG4
0.010 GeneticVariation disease BEFREE FGFR fusions retaining the kinase domain were identified in 0.2% of NSCLC cases; they included 37 fibroblast growth factor receptor gene 3 (FGFR3)-transforming acidic coiled-coil containing protein 3 gene (TACC3) fusion-positive cases, two fibroblast growth factor receptor 2 (FGFR2)-shootin 1 gene (KIAA1598 [also known as SHTN1]) fusion-positive cases, one BCL2 associated athanogene 4 gene (BAG4)-fibroblast growth factor receptor 1 gene (FGFR1) fusion-positive case, and 12 novel FGFR1, FGFR2, FGFR3, and fibroblast growth factor receptor 4 gene (FGFR4) fusion-positive cases. 30267839 2019
Entrez Id: 160418
Gene Symbol: TMTC3
0.010 GeneticVariation disease BEFREE Factors associated with improvement in symptoms and quality of life for first-line EGFR-tyrosine kinase inhibitor treatment in patients with <i>EGFR</i>-mutated non-small-cell lung cancer - A multicenter prospective SMILE study. 31417660 2019