Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. 18676761 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Effects of marine oil-enriched diets on guinea pig megakaryocyte and platelet lipids: effects on thromboxane synthesis and platelet function. 2302402 1990
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Activity of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring rare epidermal growth factor receptor mutations. 21841502 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR "Effectiveness of tyrosine kinase inhibitors on ""uncommon"" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer." 21531810 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Prognostic factors for gefitinib-treated postoperative recurrence in non-small cell lung cancer. 18176089 2007
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 CausalMutation disease CLINVAR Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. 19047918 2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 CausalMutation disease CLINVAR EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. 18594010 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. 16187797 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 CausalMutation disease CLINVAR Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. 19029981 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. 15623594 2004
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 CausalMutation disease CLINVAR Erlotinib for frontline treatment of advanced non-small cell lung cancer: a phase II study. 17062680 2006
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 CausalMutation disease CLINVAR Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. 18794081 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. 16533793 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants. 16205628 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. 15710947 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR "EGF receptor gene mutations are common in lung cancers from ""never smokers"" and are associated with sensitivity of tumors to gefitinib and erlotinib." 15329413 2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I). 20522446 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma. 19096302 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. 22753918 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 CausalMutation disease CLINVAR Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome. 17704260 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib. 23102728 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors. 23242437 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. 16115929 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CGI
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700 CausalMutation disease CLINVAR Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes. 21572125 2011