×
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.330
CausalMutation
disease
CGI
×
Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
0.320
CausalMutation
disease
CGI
×
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
0.120
CausalMutation
disease
CLINVAR
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700
CausalMutation
disease
CLINVAR
"Effectiveness of tyrosine kinase inhibitors on ""uncommon"" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer."
21531810 2011
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700
CausalMutation
disease
CLINVAR
"EGF receptor gene mutations are common in lung cancers from ""never smokers"" and are associated with sensitivity of tumors to gefitinib and erlotinib."
15329413 2004
×
Entrez Id: 494327
Gene Symbol: MIR378A
MIR378A
0.050
Biomarker
disease
BEFREE
"Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis."
23725371 2013
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700
GeneticVariation
disease
BEFREE
"Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer .
21865399 2011
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100
Biomarker
disease
BEFREE
<b>Abbreviations used:</b> TRAIL: Tumor necrosis factor -related apoptosis-inducing ligand; CLR: Curcumae longae Rhizoma; CR: Coptidis Rhizoma; NSCLC: non-small cell lung cancer .
29720822 2019
×
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.080
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK : AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 5564
Gene Symbol: PRKAB1
PRKAB1
0.070
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK : AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 5563
Gene Symbol: PRKAA2
PRKAA2
0.070
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK : AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 10533
Gene Symbol: ATG7
ATG7
0.050
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7 : autophagy related 7 ; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 8678
Gene Symbol: BECN1
BECN1
0.100
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1 : beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 10114
Gene Symbol: HIPK3
HIPK3
0.030
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3 ; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3 : homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
0.050
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH : glyceraldehyde-3-phosphate dehydrogenase ; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.320
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R : interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
MAP1LC3B
0.040
AlteredExpression
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta ; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 5987
Gene Symbol: TRIM27
TRIM27
0.020
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP : red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 2358
Gene Symbol: FPR2
FPR2
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP : red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100
Biomarker
disease
BEFREE
<b>Aims</b>: Immunohistochemistry of PD-L1 has been recently established as a surrogate method to predict if immunotherapy targeting PD-L1/PD-1 has a significant effect on suppression of cancers such as lung non-small cell carcinoma , melanoma, and renal cell carcinoma.
30588196 2018
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.700
Biomarker
disease
BEFREE
<b>Background</b>: Afatinib is a second-generation epidermal growth factor receptor -tyrosine kinase inhibitor (EGFR -TKI) that has been approved by the Food and Drug Administration for the treatment of advanced non-small cell lung cancer (NSCLC ) harboring EGFR mutations.
30854094 2019
×
Entrez Id: 442906
Gene Symbol: MIR338
MIR338
0.080
AlteredExpression
disease
BEFREE
<b>Background</b>: Circular RNAs (circRNAs) play a pivotal regulatory role in a variety of tumors.Nevertheless, the detailed function of circ_0000003 in non-small cell lung cancer (NSCLC) and its regulatory mechanism remain elusive.<b>Methods</b>: RT-PCR was carried out to detect the expressions of circ_0000003, miR-338 -3p and insulin receptor substrate 2 (IRS2)in NSCLC tissues.
31736412 2019
×
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
0.050
Biomarker
disease
BEFREE
<b>Background</b>: Circular RNAs (circRNAs) play a pivotal regulatory role in a variety of tumors.Nevertheless, the detailed function of circ_0000003 in non-small cell lung cancer (NSCLC) and its regulatory mechanism remain elusive.<b>Methods</b>: RT-PCR was carried out to detect the expressions of circ_0000003, miR-338-3p and insulin receptor substrate 2 (IRS2 )in NSCLC tissues.
31736412 2019
×
Entrez Id: 339896
Gene Symbol: GADL1
GADL1
0.100
Biomarker
disease
BEFREE
<b>Background</b>: MicroRNAs (miRNAs) are becoming recognized as novel diagnostic and prognostic biomarkers in several malignancies, including non-small-cell lung cancer (NSCLC ). miR-25 is overexpressed in small cell lung cancer (SCLC) and NSCLC tissues, and high miR-25 expression is associated with poorer overall survival of women with lung ADC .
30919763 2019
×
Entrez Id: 113451
Gene Symbol: AZIN2
AZIN2
0.100
Biomarker
disease
BEFREE
<b>Background</b>: MicroRNAs (miRNAs) are becoming recognized as novel diagnostic and prognostic biomarkers in several malignancies, including non-small-cell lung cancer (NSCLC ). miR-25 is overexpressed in small cell lung cancer (SCLC) and NSCLC tissues, and high miR-25 expression is associated with poorer overall survival of women with lung ADC .
30919763 2019