| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.460 | AlteredExpression | disease | BEFREE | Cisplatin treatment increased the expression of miR-29c and decreased the expression of its oncogenic target AKT2 in NSCLC cell lines. | 29789623 | 2018 | ||||
|
0.460 | Biomarker | disease | BEFREE | Taken together, the results of the present study suggested that microRNA-137-regulated AKT2 inhibits tumor growth and sensitizes cisplatin in patients with NSCLC. | 30008879 | 2018 | ||||
|
0.460 | Biomarker | disease | BEFREE | We present the first evidence that miR-608 behaves as a tumour suppressor in A549 and SK-LU-1 cells through the regulation of AKT2, suggesting that selective targeting of AKT2 via miR-608 may be developed as a potential therapeutic strategy for miRNA-based non-small cell lung cancer (NSCLC) therapy. | 29075783 | 2017 | ||||
|
0.460 | Biomarker | disease | BEFREE | Hyperphosphorylation of rpS6, probably regulated by the Akt2/mTOR/p70S6K signaling pathway, is closely relevant to the progression of NSCLC and it might be served as a promising therapeutic target for NSCLC treatment. | 26490682 | 2015 | ||||
|
0.460 | GeneticVariation | disease | CLINVAR | Prospective enterprise-level molecular genotyping of a cohort of cancer patients. | 25157968 | 2014 | ||||
|
0.460 | Biomarker | disease | BEFREE | Together, our findings suggest that adding chloroquine to EGFR and AKT inhibition has the potential to improve tumor responses in EGFR M+ NSCLC, and that selective targeting of AKT2 may provide a new treatment option in NSCLC. | 24946858 | 2014 | ||||
|
0.460 | GeneticVariation | disease | CLINVAR | AKT1 and AKT2 mutations in lung cancer in a Japanese population. | 21479466 | 2012 | ||||
|
0.460 | GeneticVariation | disease | BEFREE | We investigated the MEK1 mutation (n = 280) and AKT2 mutation (n = 273) in surgically treated non-small cell lung cancer cases. | 20354455 | 2010 | ||||
|
0.460 | CausalMutation | disease | CGI |