Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 AlteredExpression disease BEFREE Research has revealed that microRNA (miR)‑4500 is downregulated in non‑small cell lung cancer (NSCLC), and miR‑4500 suppresses tumor growth by targeting lin‑28 homolog B and NRAS proto‑oncogene, GTPase. 31638206 2019
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 Biomarker disease BEFREE In total 50 plasma samples from patients newly diagnosed with advanced NSCLC or resistant to first-line tyrosine kinase inhibitors (TKIs) were subjected to deep sequencing on a seven-gene panel (BRAF, EGFR, ERBB2, KRAS, NRAS, PIK3CA, PTEN) incorporated with molecular barcodes to improve accuracy in variant detection. 30268455 2018
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 Biomarker disease BEFREE In this study, we assessed 179 clinical cases of non-small cell lung carcinoma (NSCLC) that had been previously tested for EGFR, KRAS, NRAS, and BRAF mutations using a novel multiplexed analytic approach that reduces wild-type signal and allows for detection of low mutation load approaching 1%, iPLEX® HS panel for the MassARRAY® System (Agena Bioscience, San Diego, CA). 28926605 2017
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 GeneticVariation disease BEFREE We identified four (two NRAS and single AKT1 and PTEN) mutations in CNS metastases of NSCLC. 28097440 2017
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 GeneticVariation disease CLINVAR Genetic mutation screen in early non--small-cell lung cancer (NSCLC) specimens. 24370118 2014
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CLINVAR Characteristics of lung cancers harboring NRAS mutations. 23515407 2013
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 GeneticVariation disease BEFREE While 95% of patients were former or current smokers, smoking-related G:C>T:A transversions were significantly less frequent in NRAS-mutated lung tumors than KRAS-mutant non-small cell lung cancer [NSCLC; NRAS: 13% (4/30), KRAS: 66% (1772/2733), P < 0.00000001]. 23515407 2013
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CLINVAR Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. 22773810 2012
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CLINVAR Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells. 19880792 2010
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CLINVAR Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. 18794081 2008
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CLINVAR Somatic mutations affect key pathways in lung adenocarcinoma. 18948947 2008
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CLINVAR BRAF mutations in papillary carcinomas of the thyroid. 14508525 2003
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918 2002
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 Biomarker disease BEFREE Alterations in 5 microsatellite loci were analyzed in tumors from 137 patients with primary non-small cell lung carcinomas that were also genotyped for the Hras1 variable number of tandem repeats (VNTR) locus. 7664270 1995
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CLINVAR ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent. 1654209 1991
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CLINVAR Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells. 6587382 1984
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
0.460 CausalMutation disease CGI