Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Patients with previously treated advanced KRAS mutant NSCLC were prospectively assigned to one of four molecularly defined cohorts based on the presence or absence of TP53 or CDKN2A alterations and received treatment with defactinib 400 mg orally BID until disease progression or intolerable toxicity. 31739184 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE The mutational profile of NSCLC revealed alterations in 27 genes, where TP53 (47.8%) and EGFR (36.7%) exhibited the highest mutation rates. 31276344 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE Moreover, LINC00342 promoted proliferation by inhibiting the expression of p53 and PTEN proteins in NSCLC cell lines. 30320899 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE <b>Purpose:</b> To evaluate the effect of NU7026, a specific inhibitor of DNA-PKcs, on DNA-double strand break (DSB) repair in a cell cycle specific manner, on the G2/M checkpoint, mitotic progression, apoptosis and clonogenic survival in non-small-cell lung carcinoma (NSCLC) cell lines with different p53 status. 31287365 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE RNA protein interaction analysis revealed that p53 was the direct binding target of LOC285194 in NSCLC. 30542733 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE TP53 stimulates the induction of apoptosis in NSCLC by axitinib and the ACD of lung CSCs through its regulatory effects on the p53/Akt/GSK3β pathways. 30832755 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Knockdown of p53 attenuated the ability of SNF to inhibit anoikis resistance and sphere formation in A549 cancer cells, suggesting that the presence of p53 in NSCLC cancer cells is involved in the sensitivity to SFN. 30365975 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Silencing AXL by covalent siRNA-gelatin-antibody nanoconjugate inactivates mTOR/EMT pathway and stimulates p53 for TKI sensitization in NSCLC. 31085346 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE In multiple NSCLC cell lines with varied p53 and EGFR status, we compared and examined the protein contents involved in EGFR-Akt-P53 signaling loop (EGFR, P-EGFR, Akt, P-Akt, p53, P-p53) by Western blot. 31360122 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Prognostic value of <i>KRAS/TP53/PIK3CA</i> in non-small cell lung cancer. 30867754 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Co-mutations of TP53 and KRAS serve as potential biomarkers for immune checkpoint blockade in squamous-cell non-small cell lung cancer: a case report. 31619231 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE Mechanistically, p53 restricts L1CAM expression through the β-catenin/Slug pathway, with levels of β-catenin and Slug positively correlating with L1CAM expression in NSCLC tumors. 30685413 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE MicroRNA-122-5p promotes the development of non-small cell lung cancer via downregulating p53 and activating PI3K-AKT pathway. 30941980 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE To validate these results, patients with NSCLC tested for KRAS and TP53 mutations and receiving chemotherapy for any stage NSCLC were selected. 30770327 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE We investigated the aberrant expression of p16 and its relationship with p53 and HPV status in primary non-small-cell lung carcinoma. 31157548 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Our data demonstrate that LBP could be a promising candidate for the treatment of NSCLC with wild-type p53. 31428569 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE The underlying mechanism demonstrated that TP53 expression deficiency or JNK inhibitor treatment could abolish PPA1-mediated NSCLC progression. 31551407 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE TP53 mutations were assessed by next-generation sequencing in aNSCLC patients treated with programmed death-1 (PD-1) blockers. 31097096 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Upregulation of miR-675-5p induced by lncRNA H19 was associated with tumor progression and development by targeting tumor suppressor p53 in non-small cell lung cancer. 31219199 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition. 31703757 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE In this study, the involvement of p53 in the cell cycle arrest and pro-apoptotic action of actinomycin V was investigated in human non-small-cell lung carcinoma A549 cells. 31601054 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE In some assay p53 activity of NSCLC ( A549 and H460) cells were blocked with pifithrin-a, prior to treatment with ZQT. 30660711 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Taken together, our results demonstrate SMYD2 is involved into cisplatin resistance through regulating p53 pathway, and might become a promising therapeutic target for cisplatin resistance in NSCLC. 31106145 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE <b>Methods:</b> Three NSCLC cell lines, H1299 (deleted p53), A549 (wild-type p53), and H23 (mutated p53), were examined in the present investigation to represent NSCLC with different p53 functions. 31114253 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE The expression of p53 in the tumor tissue of NSCLC patients was significantly reduced in comparison with PTLC, and its expression was negatively correlated with the pathological stage, lymph node metastasis, and was positively correlated with the degree of differentiation. 31186777 2019