Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE The phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT), MEK/ERK pathway and TGF‑β are targets of NSCLC drugs that are already approved or are currently under investigation. 30535430 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE These data suggest that cardamonin suppressed NSCLC cell proliferation and inhibited metastasis partly by restraining the PI3K/Akt/mTOR pathway and it might be an effective therapeutic compound for NSCLC in the future. 30640793 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE Although the role of EGFR in PI3K/Akt signaling cascade in NSCLC is extensively studied, the molecular link between EGFR and p53 and the role of ROS in pathogenesis of NSCLC are limitedly addressed. 31360122 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE miR-496 suppress tumorigenesis via targeting BDNF-mediated PI3K/Akt signaling pathway in non-small cell lung cancer. 31421833 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE MicroRNA-122-5p promotes the development of non-small cell lung cancer via downregulating p53 and activating PI3K-AKT pathway. 30941980 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE We assessed whether buparlisib, a class 1 PI3K inhibitor, can be safely combined with radiotherapy in patients with non-small cell lung carcinoma (NSCLC) and investigated its effect on tumour hypoxia. 30991262 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 AlteredExpression disease BEFREE The activity of PI3Kα-selective inhibition against KRAS-mutated NSCLC remains largely unknown. 31119047 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE Our in vitro studies suggested that activation of EGFR signaling and/or genetic alteration of downstream effectors like PIK3CA were alternative resistance mechanisms used by capmatinib-resistant NSCLC cell lines. 30309221 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE AZD9291 promotes autophagy and inhibits PI3K/Akt pathway in NSCLC cancer cells. 30145802 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 AlteredExpression disease BEFREE The present findings suggested that treatment with pemetrexed may exhibit synergistic effects with PTEN on lung cancer cells via the inhibition of the PI3K/AKT/mTOR signaling pathway and through carbohydrate metabolism, and treatment with pemetrexed combined with PTEN overexpression may represent a novel therapeutic strategy for the treatment of NSCLC. 31485626 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE Antitumor Activity of DFX117 by Dual Inhibition of c-Met and PI3Kα in Non-Small Cell Lung Cancer. 31060329 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway. 31114247 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE We have conducted this study to check the effect of VCN-2 on the cell viability and the effect on PTEN (Phosphatase and tensin homolog), PI3KCA (Phosphatidylinositol 4, 5-biphosphate 3-kinase catalytic subunit alpha isoform/PI3K 110α subunit), and Akt1 when VCN-2 was used alone and in combination with radiation in the NSCLC cell line NCI-H23 (H23). 30496626 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE Here, we explored the therapeutic effects of co-inhibition of PI3K and mTOR in non-small-cell lung cancer (NSCLC) cells with different EGFR status. 31262325 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling. 31024010 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 AlteredExpression disease BEFREE BRD4 upregulation inhibited activation of the PI3K/Akt pathway in NSCLC cells <i>in vitro</i> and <i>in vivo</i>. 31213835 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE HYSA suppressed LPS-mediated proliferation, migration, invasion, and EMT in A549 and H1299 cells by inhibiting the PI3K/Akt/mTOR and ERK/MAPK signaling pathways, indicating that HYSA may be a potential candidate to treat inflammation-mediated NSCLC. 31055884 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE Mechanistically, miR-31 directly repressed RASA1 and FIH-1 expression, and thus, at least partially activated the RAF-MEK-ERK and PI3K-AKT signaling pathways in NSCLC with acquired resistance to gefitinib. 31762810 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE Collectively, our results, both <i>in vivo</i> and <i>in vitro</i>, demonstrate that BBD leads to autophagic cell death through downregulating the PI3K/AKT/mTOR signaling pathway and improved the antitumor effects of cisplatin in non-small cell lung cancer (NSCLC). 31497240 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE Further analyses identified an integrin β3-mediated ternary complex comprising NRP1-integrin β3-KRAS<sup>MUT</sup> and its downstream signaling of PI3K-Akt and RalB-TBK1 as a primary resistance mechanism of KRAS<sup>MUT</sup> NSCLC to cetuximab treatment. 31521695 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE <b>Conclusion:</b> Taken together, we proved that miR-224 might play essential roles in cellular functions of nutrient-depleted A549 cells possibly through regulating the target PTEN and downstream signal PI3K, suggesting the potential of miR-224 to be a therapeutic target for NSCLC therapy. 31190892 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE However, there is a lack of information about the ability of PolyI:C to affect PI3K/Akt/p53 signaling pathway in non-small cell lung cancer (NSCLC), and its pharmacodynamic evaluation in vivo still remain unclear so far. 31105808 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 Biomarker disease BEFREE The present study explored the association between <i>KRAS proto-oncogene GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) and tumor protein p53 (TP53) mutations, and the clinical features and survival prognosis in 50 patients with non-small cell lung cancer (NSCLC). 30867754 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 AlteredExpression disease BEFREE Low levels of IFNγ endowed cancer stem-like properties via the intercellular adhesion molecule-1 (ICAM1)-PI3K-Akt-Notch1 axis, whereas high levels of IFNγ activated the JAK1-STAT1-caspase pathway to induce apoptosis in non-small cell lung cancer (NSCLC). 31085700 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.500 AlteredExpression disease BEFREE Tumor-associated inflammatory microenvironment in non-small cell lung cancer: correlation with FGFR1 and TLR4 expression via PI3K/Akt pathway. 30854106 2019