Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease HPO
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease CTD_human
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. 8986805 1996
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE We demonstrate that the cytogenetically defined translocation t(X;1)(p11.2;p34) observed in papillary renal cell carcinomas results in the fusion of the splicing factor gene PSF located at 1p34 to the TFE3 helix-loop-helix transcription factor gene at Xp11.2. 9393982 1997
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE Association with the cellular splicing machinery is therefore, a common feature of the proteins that become fused to TFE3 in papillary renal cell carcinomas. 11313942 2001
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE The prime candidate within this previously fully sequenced region was TFE3, a transcription factor gene known to be fused to translocation partners on 1 and X in some papillary renal cell carcinomas. 11244503 2001
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE The papillary renal cell carcinoma (RCC)-associated (X;1)(p11;q21) translocation fuses the genes PRCC and TFE3 and leads to cancer by an unknown molecular mechanism. 11717438 2001
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents. 11438465 2001
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas. 11358836 2001
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE We analyzed a series of sporadic type 1 and type 2 PRCC cases for MET mutations, TFE3 rearrangements, and allelic imbalance (AI) on 3p, 6, 7q, 9p, 11, 13q, 14q, 17q, 18, 20q, and 21q and compared selected results with a series of conventional renal cell carcinomas. 12213728 2002
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE We report the cloning of a novel clathrin heavy-chain gene (CLTC)-TFE3 gene fusion resulting from a t(X;17)(p11.2;q23) in a renal carcinoma arising in a 14-year-old boy. 12917640 2003
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Previously, we demonstrated that in t(X;1)(p11;q21)-positive renal cell carcinomas (RCCs), the TFE3 gene on the X chromosome is disrupted and fused to the PRCC gene on chromosome 1. 12837690 2003
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE Translocations of TFE3 occur in specific subsets of human renal cell carcinomas and in alveolar soft part sarcomas. 12719541 2003
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE This classification includes the recently described renal cell carcinomas with the ASPL-TFE3 gene fusion and carcinomas with a PRCC-TFE3 gene fusion. 15316311 2004
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 AlteredExpression disease BEFREE Establishment and characterization of a renal cell carcinoma cell line (FU-UR-1) with the reciprocal ASPL-TFE3 fusion transcript. 15138551 2004
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 AlteredExpression disease BEFREE Translocations of the genes encoding the related transcription factors TFE3 and TFEB are almost exclusively associated with a rare juvenile subset of renal cell carcinoma and lead to overexpression of TFE3 or TFEB protein sequences. 15994295 2005
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE We reported a case of a 2-year-old boy with RCC associated with TFE3 translocation resulting in a PRCC-TFE3 fusion gene. 16010549 2005
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE Cytogenetic analysis revealed a karyotype of t(X;1)(p11.2; p34.3), consistent with a TFE3-associated RCC. 15383938 2005
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE This study suggests that many cases of RCC in children reported under the terms "papillary" and "clear cell" likely represent Xp11.2 translocation/TFE3 gene fusion-associated RCC. 15747097 2005
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Kidney carcinoma associated with Xp11.2 translocation / TFE3 (ASPL-TFE3) gene fusion. 15992428 2005
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Recently, a unique translocation between the X chromosome and chromosome 1 or t(X;1) has been described in several reports of renal cell carcinomas (RCCs) diagnosed in children and adolescents that results in PRCC-TFE3 gene fusion. 16807766 2006
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE Moreover, MITF and TFE3 reciprocally rescue one another in lines derived from CCS or pediatric renal carcinoma. 16766266 2006
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE These findings correspond to the recently described Xp11.2 translocation/TFE3 fusion renal cell carcinoma. 17121198 2006
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE The recently recognized Xp11 translocation renal cell carcinomas (RCCs), all of which bear gene fusions involving the TFE3 transcription factor gene, comprise at least one-third of pediatric RCC. 17667536 2007
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE Oncogenic TFE3 fusion proteins define a subset of pediatric renal adenocarcinomas and one fusion (ASPL-TFE3) is also characteristic of alveolar soft part sarcoma (ASPS). 17283122 2007