Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease HPO
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease CTD_human
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Kidney carcinoma associated with Xp11.2 translocation / TFE3 (ASPL-TFE3) gene fusion. 15992428 2005
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Renal cell carcinomas associated with Xp11.2 translocations ( TFE3 gene fusions) are rare tumors predominantly reported in children. 17580272 2007
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Renal cell carcinoma associated with TFE3 gene fusion in an elderly woman. 17905124 2007
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 AlteredExpression disease LHGDN Renal cell carcinoma associated with TFE3 gene fusion in an elderly woman. 17905124 2007
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Renal cell carcinomas (RCC) associated with Xp11.2 translocations (transcription factor E3 gene fusions) are rare tumors predominantly reported in children. 19815489 2009
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: radiological findings mimicking papillary subtype. 21182142 2011
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Renal cell carcinomas (RCCs) with Xp11 translocation (Xp11 RCC) constitute a distinctive molecular subtype characterized by chromosomal translocations involving the Xp11.2 locus, resulting in gene fusions between the TFE3 transcription factor with a second gene (usually ASPSCR1, PRCC, NONO, or SFPQ). 28411178 2017
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE TFE3-positive renal cell carcinoma occurring in three children with dysfunctional kidneys on immunosuppression. 28322484 2017
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE TFE3 regulates renal adenocarcinoma cell proliferation via activation of the mTOR pathway. 28713889 2017
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 AlteredExpression disease BEFREE TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas. 30849994 2019
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Transcription factor E3 (TFE3) is a useful marker for tumors with Xp11.2 translocation, including alveolar soft part sarcoma and renal cell carcinoma. 31788112 2019
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE A case of PSF-TFE3 gene fusion in Xp11.2 renal cell carcinoma with melanotic features. 25582502 2015
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE A novel case of t(X;1)(p11.2;p34) in a renal cell carcinoma with TFE3 rearrangement and favorable outcome in a 57-year-old patient. 20620589 2010
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE A recently described subtype of renal cell carcinoma (RCC) bearing chromosome translocations involving a breakpoint at Xp11 and resulting in gene fusions involving the TFE3 transcription factor gene often presents in the pediatric population. 17656236 2007
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE A retrospective review was conducted to describe the clinical characteristics and outcome of adult patients with metastatic Xp11.2 RCC who had strong TFE3 nuclear immunostaining and received anti-VEGF therapy. 20665500 2010
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE A total of five TFE3 gene fusions (PRCC-TFE3, ASPSCR1-TFE3, SFPQ-TFE3, NONO-TFE3, and CLTC-TFE3) and one TFEB gene fusion (MALAT1-TFEB) have been identified in RCC tumours and characterized at the mRNA transcript level. 25048860 2014
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Adult-onset renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: 3 case reports and review of literature. 29901594 2018
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE All 7 PRCC-TFE3 RCCs showed positive cathepsin K immunoreactivity. 28949976 2017
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Although rare, RBM10-TFE3 fusion variant (from chromosome X paracentric inversion), therefore, appears to be a recurrent molecular event in Xp11.2 RCCs. 26998913 2016
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 GeneticVariation disease BEFREE Among a total of 1130 identified renal cell carcinomas, 21 cases (1.9%) showed rearrangement of the TFE3 (n = 20) or (TFEB) (n = 1) gene. 28106924 2017
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE Among the 27 renal cell carcinomas with TFE3 strong positive immunostaining, 20 cases were diagnosed as Xp11 translocation renal cell carcinoma, and seven cases were diagnosed as clear cell renal cell carcinoma. 31175325 2019
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE Any RCC positive for TFE3 and lacking a translocation should be tested for ALK expression and translocation. 27450657 2016
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
0.500 Biomarker disease BEFREE Association with the cellular splicing machinery is therefore, a common feature of the proteins that become fused to TFE3 in papillary renal cell carcinomas. 11313942 2001