×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
HIF-2α is stabilized in von Hippel-Lindau (VHL)-deficient renal cell carcinoma through mechanisms that require ongoing mRNA translation.
22869144
2013
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
Our findings also suggest that MTHFD2 and HIF-2α form a positive feedforward loop in RCC , promoting metabolic reprograming and tumor growth.
31289360
2019
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
Herein, we provide mechanistic evidence that HIF-2α can be degraded in cytoplasm under hypoxic conditions via the 26S proteasome and that MDM2 is the E3 ligase which induces the hypoxic degradation of HIF-2α in PI-3K-dependent manner in VHL-deficient RCC cells.
25578041
2015
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
A small molecule inhibitor that binds to HIF-2α and blocks dimerization with HIF-1β is in clinical trials for the treatment of renal cell carcinoma .
30625281
2019
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma .
20032376
2009
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
Our data provide insight into the link between HIF2α , the ITPR1-related pathway, and natural immunity and strongly suggest a role for the HIF2α/ITPR1 axis in regulating RCC cell survival.
25297632
2014
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
AlteredExpression
disease
BEFREE
Furthermore, we demonstrate that peroxisome abundance is reduced in VHL-deficient human clear cell renal cell carcinomas with high HIF-2α levels.
25440060
2014
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
AlteredExpression
disease
BEFREE
Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression.
23940778
2013
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
Cell culture metabolomics analysis was utilized to determined effect of VHL and HIF-1α or HIF-2α on metabolism of renal cell carcinomas (RCC ).
26620126
2016
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
GeneticVariation
disease
BEFREE
Two correlated variants (r² = 0.99 in controls), rs11894252 (P = 1.8 × 10⁻⁸) and rs7579899 (P = 2.3 × 10⁻⁹), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha , a transcription factor previously implicated in RCC .
21131975
2011
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
GeneticVariation
disease
BEFREE
Somatic mutations in HIF2A have been reported in PPGLs associated with polycythemia, which have been reported to also be present in patients with RCC s and HBs.
26514359
2016
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
HIF2α is involved in the expansion of CXCR4-positive cancer stem-like cells in renal cell carcinoma .
26439684
2015
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
Androgen receptor (AR) signaling may promote renal cell carcinoma (RCC ) progression via altered HIF-2α /VEGF signaling.
27848972
2016
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
GeneticVariation
disease
BEFREE
PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α -Targeting Therapy for Renal Cell Carcinoma .
28951458
2017
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
AlteredExpression
disease
BEFREE
Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma .
16230378
2005
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
GeneticVariation
disease
BEFREE
Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1 ).
31231134
2019
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
New treatment modalities targeted to HIF-1α and HIF-2α might be planned as well as VEGF-targeted therapies in the management of clear cell renal cell carcinomas .
27583351
2017
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
While HIF1α can act as a ccRCC tumor suppressor, HIF2α has emerged as the key HIF isoform that is essential for ccRCC tumor progression.
29938199
2018
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
EPAS1 was detected in all of the RCC cell lines examined.
11301389
2001
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
AlteredExpression
disease
BEFREE
Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2α activity.
24189146
2014
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
AlteredExpression
disease
BEFREE
We show that DNA-PKcs over-expression regulates mTORC2-AKT activation, HIF-2α expression and RCC cell proliferation.
27412013
2016
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
AlteredExpression
disease
BEFREE
We find that DDT expression mirrors MIF expression in ccRCC tumor sections with high correlation and that, mechanistically, DDT is a novel hypoxia-inducible gene and direct target of HIF1α and HIF2α .
24356968
2014
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
GeneticVariation
disease
BEFREE
HIF2A germline-mutation-induced polycythemia in a patient with VHL-associated renal-cell carcinoma .
29172931
2017
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
Biomarker
disease
BEFREE
Knockdowns of TRAIL averted apoptotic cell death caused by HIF2-alpha inhibition in starvation-resistant RCC s.
29796174
2018
×
Entrez Id:
2034
Gene Symbol:
EPAS1
EPAS1
0.700
AlteredExpression
disease
BEFREE
In determining the critical functions for HIF2α expression in RCC cells, the NADPH oxidase NOX4 has been identified, but the pathogenic contributions of NOX4 to RCC have not been evaluated directly.
24755467
2014