Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE We investigated the effect of suppressor of cytokine signaling (SOCS) 3 on the expression of TRAIL receptors (DR4) and on TRAIL sensitivity in renal cell carcinoma (RCC) cells. 30167088 2018
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. 30504817 2018
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE In addition, high abundance of TRAIL was correlated with poor prognosis in patients with RCC, suggesting that TRAIL, followed by HIF2-alpha and c-FLIP, play a role in the survival and/or progression of malignant RCCs. 29796174 2018
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE An inhibitor of cathepsin G [Cathepsin G inhibitor I (Cat GI); CAS 429676-93-7] markedly induced TRAIL-mediated apoptosis in human renal carcinoma (Caki, ACHN, and A498), lung cancer (A549) and cervical cancer (Hela) cells. 29290980 2017
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Activation of this pathway might represent a useful strategy to overcome the cell-inherent resistance to cancer therapeutics, including TRAIL, in multiresistant cancers such as RCC. 28154184 2017
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Galangin alone and TRAIL alone had no effect on apoptosis, while combined treatment with galangin and TRAIL significantly induced apoptosis in renal carcinoma (Caki, ACHN and A498) but not normal cells (normal mouse kidney cells and human normal mesangial cells). 26725939 2016
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE The objective of this study was to determine the effectiveness of combining the diterpene triepoxide triptolide, or its water-soluble prodrug, Minnelide, with TRAIL receptor agonists against RCC in vitro or in vivo, respectively. 26426449 2015
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Here, we investigated the effect of RU486 on TRAIL-induced apoptosis in human renal carcinoma Caki cells. 22008998 2012
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Therapeutic disease CTD_human The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP. 20403343 2010
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE Differential gene expression in anticancer drug- and TRAIL-mediated apoptosis in renal cell carcinomas. 17610067 2007
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE These findings suggest that TRAIL gene therapy and/or 5-FU may be effective against renal cell carcinoma without harmful toxic effects. 16985049 2006
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Our results demonstrate the utility of combining Ad5-TRAIL with HDACi against RCC, and mechanistically define how this combination modulates RCC sensitivity to TRAIL/Apo-2L and adenoviral infection. 16456549 2006
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE We concluded that in the presence of an intact TRAIL signaling pathway, a significant reduction of cFLIP alone is sufficient to sensitize human RCCs to TRAIL apoptosis. 15614529 2005
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE These results indicate that combination therapy of HDACI, such as sodium butyrate and trichostatin A, and TRAIL/Apo-2L has great potential for an efficient alternative therapy for renal cell carcinoma. 16096370 2005
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE These data suggest that RCC can be classified into two subsets: TRAIL-sensitive RCC with a low NF-kappaB activity and TRAIL-resistant RCC with constitutively activated NF-kappaB. 11439352 2001
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE This synergistic effect of cotreatment with Topotecan and TRAIL may provide the basis for a new therapeutic approach to induce apoptosis in otherwise unresponsive RCC. 11139287 2000