| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | PosttranslationalModification | disease | BEFREE | To this end, aberrant promoter methylation of ABCG2 has been reported to cause its repression in a few cancer types including renal carcinoma and multiple myeloma. | 27253631 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | In this study, we took a different approach to focus on the regulatory mechanism in RCC-CIC and unveil DAB2IP-mediated miR-138 expression that plays a critical role in modulating stem-like phenotypes in RCC via targeting the ABC transporter (ABCA13) as well as oncogenic histone methyltransferase EZH2 while down regulation of miR-138 gene expression in RCC is due to epigenetic gene silencing by DNA methyltransferase 1 (DNMT1). | 28978010 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | This study is to investigate the association of a functional germline variant on ABCG2 that affects the pharmacokinetics of sunitinib with sunitinib-induced toxicity of RCC patients in the Japanese population. | 26914831 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | We hypothesized that inhibition of multidrug resistant transporters by elacridar (dual inhibitor of P-glycoprotein and ABCG 2) might overcome sunitinib resistance in experimental renal cell carcinoma. | 25455500 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma. | 24825438 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Sequence mutations of the substrate binding pocket of stem cell factor and multidrug resistance protein ABCG2 in renal cell cancer: a possible link to treatment resistance. | 23467750 | 2013 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | Aberrant promoter methylation of the ABCG2 gene in renal carcinoma. | 16954373 | 2006 | ||||
|
0.080 | Biomarker | disease | BEFREE | These data suggest that BCRP is a candidate RCC susceptibility gene. | 15906349 | 2005 |