Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE Analysis of p16 expression and allelic imbalance / loss of heterozygosity of 9p21 in cutaneous squamous cell carcinomas. 16989737 2007
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease LHGDN Alterations of the p14ARF-p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event. 16142358 2005
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE This study aimed to link expression patterns of AQP1, AQP5, Bcl-2 and p16 to clinicopathological characteristics of oro-hypopharyngeal squamous cell carcinomas. 26074259 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 GeneticVariation disease BEFREE The results of methylation analysis, in combination with the results of our previous mutation analysis of CDKN2A locus and p53, revealed that 70% of SCCs have alterations in the RB1/p16 or p53 pathway. 17034532 2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 PosttranslationalModification disease BEFREE However, FHIT methylation in 125 squamous cell carcinomas was associated with exposure to tobacco smoke and p16 methylation, but not with age, gender and pathologic stage. 15231689 2004
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.700 Biomarker disease HPO
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE The combination of the lack of p16INK4 and/or Rb expression increased from benign lesions (14.3%), through VIN I (60%) and VIN III (60%), to invasive squamous cell carcinoma (72%), thus supporting the postulation that alterations in p16INK4 or Rb could be significant events in progression of disease. 9514803 1998
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 GeneticVariation disease UNIPROT
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 GeneticVariation disease BEFREE Homozygous deletion of p16 appears to be common in esophageal squamous cell carcinomas but in adenocarcinomas, both gene deletion and transcriptional silencing of p16 were infrequent. 9333024 1997
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE We analyzed 209 samples of head and neck SCC to establish a predictive cutoff for p16 and determine the role of p16 positivity in OTs versus non-OTs. 26481441 2016
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.700 GeneticVariation disease LHGDN Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population. 12124811 2002
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE Nine (69%) SCC showed loss of p16 expression and 10 (77%) showed expression of BMI-1. 15892997 2005
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease BEFREE This study investigated the immunohistochemical expression of retinoblastoma (RB) protein and p16 protein in 10 neuroendocrine carcinomas (NECs), in comparison to two mixed-type NECs; 28 squamous cell carcinomas (SCCs), and 12 carcinosarcomas (CSs) from patients with esophageal cancer. 30952735 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 GeneticVariation disease LHGDN Reduced expression of the p16 protein was observed in 18 SCC (86%), while p16 gene alterations (hypermethylation (29%) and point mutation (33%)) were found in 11 (52%). 19067849 2008
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE Mutations of the cell cycle regulatory genes p16INK4A and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour suppressor gene status and data on survival in oropharyngeal squamous cell carcinomas. 14981901 2004
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.700 Biomarker disease BEFREE For ERCC2 Gln751Gln, the association was significant for both SCCs (P=0.001, OR=10.1, 95% CI=2.6-37.9) and SILs (P=0.001, OR=8.9, 95% CI=2.8-28.3). 25812040 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 AlteredExpression disease LHGDN [The expression of p53, p16, cyclin D1 in esophageal squamous cell carcinoma and esophageal dysplasia]. 17060721 2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE We retrospectively included 50 histologically confirmed p16 positive oropharyngeal squamous cell carcinomas (p16 positive immunostaining was defined by a strong staining in 70% or more of tumor cells). 29925856 2018
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.700 GeneticVariation disease BEFREE Both of CCNH-V270A C/C or C/T and XPD 751 A/A showed a significant longer survival in the squamous cell carcinoma subgroup (P=0.047 and P=0.034 respectively). 21676483 2012
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.700 GeneticVariation disease BEFREE Are XPD and XPG gene variants related to the mechanism of oral squamous cell carcinoma? 30672443 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE We investigated the methylation status of the chromosome 9p21 gene cluster (p14(ARF), p15(INK4b) and p16(INK4a) genes) by methylation-specific polymerase chain reaction in 20 central and 40 peripheral types of pulmonary squamous cell carcinoma (SqCC) in order to determine the differences between the pathogeneses of the central and peripheral types of SqCC. 15260845 2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 PosttranslationalModification disease BEFREE Molecular staging of surgical margins in oral squamous cell carcinoma using promoter methylation of p16(INK4A), cytoglobin, E-cadherin, and TMEFF2. 23111707 2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 Biomarker disease BEFREE We performed immunohistochemical studies using anti‑cyclin D1, anti‑cyclin E, anti‑pRb, anti‑p53, anti‑p16INK4a, and anti‑Ki‑67 antibodies in normal skin, psoriatic epidermal tissue, and squamous cell carcinoma (SCC) tissue. 29115643 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 PosttranslationalModification disease BEFREE The methylation of p16 is correlated with smoking history and methylation of HPP1 was significantly more frequent in adenocarcinomas than in squamous cell carcinomas. 15201980 2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.700 PosttranslationalModification disease BEFREE Methylation of APC, CCND2, KCNH5 and, RUNX was significantly more frequent in adenocarcinomas compared to squamous cell carcinomas (SCC), while methylation of CDKN2A was more common in SCC. 19945765 2010