Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.100 Biomarker disease BEFREE In silico screening of candidate therapeutic compounds using subtype-specific pathway components identified HDAC and PI3K inhibitors as potential treatments tailored to lung SqCC. 22629454 2012
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.100 PosttranslationalModification disease BEFREE Knockdown of PLC-γ1 or PIKE blocked EGF-induced activation of class Ia PI3K and protein kinase C-ζ and phosphorylation of nucleolin in the nucleus as well as EGF-induced SCC cell proliferation. 22349826 2012
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.100 Biomarker disease BEFREE EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy. 21110697 2011
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.100 Biomarker disease BEFREE Activation of the PI3K/AKT signalling pathway has been reported both in squamous cell carcinoma (SCC) of the skin and in basal cell carcinoma (BCC). 20557351 2010
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.100 AlteredExpression disease BEFREE The majority of OSCC cell lines showed an activation of PI3K/Akt signaling, and enforced expression of NDRG2 in HSC-3 cells decreased the level of phosphorylated Akt at Serine 473 (p-Akt). 20045673 2010
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.100 GeneticVariation disease BEFREE After SCC transformation, the absence of G45 domain in DeltaG45 cells was associated with deficient extracellular signal-regulated kinase and phosphotidylinositol 3-kinase (PI3K) pathway activation, impaired invasion, deficient metalloproteinase activity, and absent tumorgenicity in vivo. 18413757 2008
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.100 Biomarker disease BEFREE Activity of the downstream PI3K effector protein kinase B (PKB) was higher in SqCas than in AdCas and was correlated with PIK3CA copy number (r = 0.75), suggesting that these copy number increases contribute to activation of PI3K signaling in SqCas of the lung. 12097266 2002