Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.560 Biomarker disease BEFREE MiR-193b Mediates CEBPD-Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells. 27918099 2017
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.560 GeneticVariation disease BEFREE Potential role of CCND1 G870A genotype as a predictor for urothelial carcinoma susceptibility and muscle-invasiveness in Taiwan. 21789902 2011
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.560 GeneticVariation disease BEFREE However, there was no association of p53 or CCND1 polymorphisms with UC risk. 18640142 2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.560 Biomarker disease RGD Deregulation of the p16-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway involved in the rat bladder carcinogenesis induced by terephthalic acid-calculi. 16896691 2006
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.560 Biomarker disease BEFREE Amplification of CCND1 or alterations in c-myc/CCND1 early in bladder cancer may have clinical relevance in promoting and predicting progression to detrusor-muscle-invasive transitional cell carcinoma. 12237776 2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.560 AlteredExpression disease BEFREE Tissue samples from 67 patients with transitional cell carcinoma were examined with an immunohistochemical stain for the expression of p16 and cyclin D1 genes. 12372886 2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.560 Biomarker disease LHGDN Amplification of CCND1 or alterations in c-myc/CCND1 early in bladder cancer may have clinical relevance in promoting and predicting progression to detrusor-muscle-invasive transitional cell carcinoma. 12237776 2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.560 Biomarker disease CTD_human Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. 12151359 2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.560 AlteredExpression disease BEFREE We analysed the expression of cyclin D1 in 75 patients with transitional cell carcinoma (TCC) to investigate the possible relationship between its expression and clinical outcome as well as histopathological findings using the immunohistochemical method. 9192983 1997
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.530 Biomarker disease BEFREE To establish an animal model mimicking invasive UC that arises from papillary non-invasive UC in the bladder, male human c-Ha-ras proto-oncogene transgenic rats (Hras128) were treated with 0.05% N-butyl-N-(hydroxybutyl)nitrosameine (BBN) in their drinking water and/or 0.1% phenylethyl isothiocyanate (PEITC) in their diet as follows: BBN (8 weeks)→PEITC (8 weeks); PEITC (8 weeks)→BBN (8 weeks); BBN alone (16 weeks); PEITC alone (16 weeks); and no treatment. 28004470 2017
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.530 AlteredExpression disease BEFREE Since 5-10% of transitional cell carcinomas (TCCs) have been shown to contain a mutated HRAS gene, and protein expression levels of all forms of HRAS have been correlated with TCC progression, we chose to study the contribution of the HRAS oncogene in bladder tumor progression. 2247480 1990
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.530 Biomarker disease BEFREE Immunocytochemical demonstration of p21ras in normal and transitional cell carcinoma urothelium. 3057152 1988
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.530 Biomarker disease CTD_human Enhanced expression of Harvey-ras oncogene in FANFT-induced transitional cell carcinoma. 3433577 1987
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.530 CausalMutation disease CGI
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE The concomitant use of USP28 and p53 to predict the progression of urothelial carcinoma of the bladder. 31822365 2020
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.400 GeneticVariation disease BEFREE Diagnostic potential of TERT promoter and FGFR3 mutations in urinary cell-free DNA in upper tract urothelial carcinoma. 30887605 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.400 GeneticVariation disease BEFREE Very recently, erdafitinib, a pan-FGFR inhibitor, has been granted accelerated approval by FDA for platinum-pretreated advanced metastatic UC with susceptible FGFR3 or FGFR2 genetic alterations. 31030123 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.400 AlteredExpression disease BEFREE Here we report several key insights from our molecular dissection of this disease: 1) Most UTUCs are luminal-papillary; 2) UTUC has a T-cell depleted immune contexture; 3) High FGFR3 expression is enriched in UTUC and correlates with its T-cell depleted immune microenvironment; 4) Sporadic UTUC is characterized by a lower total mutational burden than urothelial carcinoma of the bladder. 31278255 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.400 GeneticVariation disease BEFREE Activating mutations of fibroblast growth factor receptor 3 (FGFR3) are common in urothelial carcinoma of the bladder (UC). 30952872 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.400 Biomarker disease BEFREE The frequency of FGFR3 aberrations was higher in bladder UC (25%) than in UC of the renal pelvis and ureter (18%) but the difference was not statistically significant (P = 0.444). 30064409 2018
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.400 AlteredExpression disease BEFREE The differential expression levels of FGFR3-AS1 and FGFR3 in tumor tissues and paired normal tissues were determined using Real-Time qPCR in a total of 36 patients diagnosed with bladder cancer (urothelial carcinoma). 29226855 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Results were compared to existing data (i.e., other series of AA-associated UC and IARC TP53 database). 28477877 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Prior to this study, the p53 null phenotype was not well described in urothelial carcinoma of the bladder. 28342221 2017
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.400 Biomarker disease BEFREE Absent clinical activity suggests that patient selection by pFGFR3 IHC alone does not enrich for response to FGFR3 kinase inhibitors in urothelial carcinoma.<i></i>. 27932416 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE Impact of the Ki-67 labeling index and p53 expression status on disease-free survival in pT1 urothelial carcinoma of the bladder. 29354488 2017