Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 GeneticVariation group BEFREE To introduce an animal model, we investigated the β1-AAB associated autoimmunity in Doberman Pinscher (DP) with dilated cardiomyopathy, which has similarities to human DCM. 31276517 2019
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 Biomarker group BEFREE Agonistically acting autoantibodies directed against the adrenergic beta-1 receptor (beta1-AABs) are a pathogenic factor in diseases of the heart and circulatory system such as dilated cardiomyopathy. 30539571 2019
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 Biomarker group BEFREE Autoantibodies to beta-1 adrenergic receptor have been reported in adult patients with dilated cardiomyopathy (DCM). 30468641 2019
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 Biomarker group BEFREE Autoantibodies directed against the second extracellular loop of the cardiac β1-adrenergic receptor (β1-AR) are thought to contribute to the pathogenesis of dilated cardiomyopathy (DCM) and Chagas heart disease. 22811559 2012
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 AlteredExpression group BEFREE The main findings were 1) the expression of the α(1A)-AR in the LV positively correlates with LVEF; 2) the expression of GRK3 and GRK5 inversely correlates with LVESD and LVEDD, supporting previous observations about a protective role for both kinases in failing hearts; and 3) β(1)-AR expression is downregulated in the LV and RV of IC, in the LV of DC, and in the RV of NINDC. 22685168 2012
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 GeneticVariation group LHGDN Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry. 18776959 2008
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 Biomarker group RGD Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction. 18287209 2008
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 GeneticVariation group LHGDN Beta1- and beta2-adrenergic receptor polymorphisms affect susceptibility to idiopathic dilated cardiomyopathy. 17667029 2007
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 GeneticVariation group BEFREE In vitro, the Gly389 variant of beta1-AR mediates less adenylyl cyclase activities than the Arg389 variant, so Arg389Gly polymorphism was investigated with regard to the genesis, progression, or arrhythmogenesis of dilated cardiomyopathy (DCM). 12197595 2002
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 GeneticVariation group LHGDN Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy. 12197595 2002
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.580 Biomarker group CTD_human Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy. 9554809 1998