×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
BEFREE
One patient with a myosin heavy-chain (MYH7 ) mutation had dilated cardiomyopathy and heart failure.
30874888
2019
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples.
27532257
2017
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
Genetic Testing in Pediatric Left Ventricular Noncompaction.
29212898
2017
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples.
27532257
2017
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
BEFREE
Here we investigate whether the same methodology can be used to develop a differential phenotype predictor, which, once a mutation has been predicted as pathogenic, is able to distinguish between phenotypes-in this case the two major clinical phenotypes (hypertrophic cardiomyopathy, HCM and dilated cardiomyopathy , DCM) associated with mutations in the beta-myosin heavy chain (MYH7 ) gene product (Myosin-7 ).
27318203
2016
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
BEFREE
In line with its expression pattern, MYH7 mutations have been reported in association with hypertrophic or dilated cardiomyopathy , skeletal myopathies or a combination of both.
27519903
2016
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
BEFREE
Homozygous MYH7 R1820W mutation results in recessive myosin storage myopathy: scapuloperoneal and respiratory weakness with dilated cardiomyopathy .
25666907
2015
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
A rare mutation in MYH7 gene occurs with overlapping phenotype.
25576864
2015
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
Prognostic Relevance of Gene-Environment Interactions in Patients With Dilated Cardiomyopathy: Applying the MOGE(S) Classification.
26383716
2015
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
The sarcomeric M-region: a molecular command center for diverse cellular processes.
25961035
2015
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
A low prevalence of sarcomeric gene variants in a Chinese cohort with left ventricular non-compaction.
24691700
2015
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
Loss of Function Mutations in NNT Are Associated With Left Ventricular Noncompaction.
26025024
2015
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
Novel mutations widen the phenotypic spectrum of slow skeletal/β-cardiac myosin (MYH7) distal myopathy.
24664454
2014
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians.
25448463
2014
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
Biomarker
group
BEFREE
Cardiac involvement may be present in MYH7 -myopathy and may be progressive between the generations, ranging from relaxation abnormality to noncompaction, ventricular arrhythmias, and dilated cardiomyopathy .
24953931
2014
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
Novel mutations widen the phenotypic spectrum of slow skeletal/β-cardiac myosin (MYH7) distal myopathy.
24664454
2014
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing.
24503780
2014
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy: overview of 10 years' experience.
23349452
2013
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
Poor prognosis of rare sarcomeric gene variants in patients with dilated cardiomyopathy.
24119082
2013
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
Cardiomyopathy mutations in the tail of β-cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes.
24047955
2013
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
Myosinopathies: pathology and mechanisms.
22918376
2013
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy.
23313350
2013
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
Uptake of cardiac screening and genetic testing among hypertrophic and dilated cardiomyopathy families.
23054336
2013
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
GeneticVariation
group
CLINVAR
A de novo germline mutation in MYH7 causes a progressive dominant myopathy in pigs.
23153285
2012
×
Entrez Id:
4625
Gene Symbol:
MYH7
MYH7
0.490
CausalMutation
group
CLINVAR
Genetic testing for dilated cardiomyopathy in clinical practice.
22464770
2012