Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE With the development of molecular biological technology, the association between genes and diseases has drawn increasing attention of researchers; the endothelial nitric oxide synthase (eNOS) gene has been reported to be a candidate gene for cardiovascular disease (CHD). 29359785 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE In this study, associations between CVDs and polymorphisms of angiotensin-converting enzyme (ACE), atrial natriuretic peptide (ANP), beta(2)-adrenal receptor (B2AR) and endothelial nitric oxide synthase (ENOS) genes were explored in a community-based setting. 17243909 2007
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been associated with the pathogenesis of cardiovascular diseases, but few studies have evaluated the role of eNOS haplotypes on the risk and prognosis of heart failure (HF). 22290017 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group LHGDN An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease. 12065317 2002
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Concomitant presence of CETP B1, NOS3 T and ANGPTL8 T alleles augments the risk of CVD and T2DM. 29973202 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE Clear is that enhanced production of reactive oxygen species (ROS) and eNOS uncoupling are relatively important causes of reduced NO-bioactivity in cardiovascular disease states. 17584103 2007
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE In this review, we discuss the basic biochemical mechanisms of NOS3 regulation and the clinical and pharmacogenetic impact of NOS3 polymorphisms on cardiovascular diseases. 27569446 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE We sought to determine whether the endothelial nitric oxide synthase (eNOS) T-786C single nucleotide polymorphism (SNP), implicated in cardiovascular disease susceptibility, could facilitate differentiation between small (< or =5 mm) versus large (> or =10 mm) ruptured aneurysms. 14576373 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE NO is synthesized from l-arginine through the action of the nitric oxide synthase (NOS) family of enzymes, which includes three isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS). iNOS-derived NO has been associated with the pathogenesis and progression of several diseases, including liver diseases, insulin resistance, obesity and diseases of the cardiovascular system. 31672462 2020
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 AlteredExpression group BEFREE Impaired endothelial function, characterized by an imbalance in endothelial Nitric Oxide Synthase (eNOS) activity, precedes and accelerates the development of CVD. 28852041 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE The distributions of the ecNOS and MTHFR genotypes did not differ significantly between the groups with and without cardiovascular disease. 10781649 2000
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE The susceptibility to nephropathy and CVD depends to some extent on genetic factors, therefore polymorphisms in the gene coding for endothelial NO-synthase, NOS3, can affect the risk of developing these diseases. 19246226 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE We therefore assessed the association of glaucoma with polymorphisms of NOS3 and CYBA previously associated with cardiovascular disease. 22919264 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE An insertion/deletion (I/D) polymorphism in the gene encoding the ACE and a single nucleotide exchange polymorphism (G894T) in the gene NOS3 encoding endothelial nitric oxide synthase have been associated with cardiovascular disorders. 12837457 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 AlteredExpression group BEFREE Expression of eNOS is altered in many types of cardiovascular disease, such as atherosclerosis, diabetes and hypertension. 18692595 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group LHGDN The present study was performed in an attempt to better understand whether metabolic, endothelial, and angiographic findings characteristic of subjects with cardiovascular disease and in-stent restenosis are related to NOS3 variants. 18349107 2008
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE A single nucleotide polymorphism G894T within exon 7 of endothelial nitric oxide synthase (eNOS-7) gene, resulting in a replacement of glutamic acid by aspartic acid, has been studied as a putative candidate gene for cardiovascular diseases. 21623032 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Several polymorphisms in the eNOS gene have been described, some of them being linked with the increased risk of cardiovascular disease, coronary heart disease (CHD), and coronary spasm. 19505886 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group LHGDN The 894T and -786C alleles of the NOS3 gene were significantly associated with both hypertension and CVD in renal allograft recipients. 18331440 2008
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE These results indicate that somatic delivery of the human eNOS gene induces a prolonged reduction of high blood pressure and raises the potential of using eNOS gene therapy for hypertension and cardiovascular diseases. 9314409 1997
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. 25034973 2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE However, we found that eNOS G894T polymorphism was associated with the presence and severity of renal disease and with CVD in CRD patients (P=0.028, P=0.018, P=0.016 respectively). 19376104 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 AlteredExpression group BEFREE Many cardiovascular diseases are associated with reduced levels of bioactive nitric oxide (NO) and an uncoupling of oxygen reduction from NO synthesis in endothelial NO synthase (eNOS uncoupling). 18252813 2008
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Surprisingly, only approximately half of these studies have demonstrated significant associations between NOS3 polymorphisms and cardiovascular disease, and many reports are contradictory. 11431031 2001
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE The Glu298Asp is a single nucleotide polymorphism (SNP) in the eNOS gene related to the risk of cardiovascular disease. 31442681 2020