Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Endothelial nitric oxide synthase (eNOS) variants were previously demonstrated in cardiovascular disease. 12716763 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. 17018701 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Endothelial nitric oxide synthase gene polymorphisms, either independently or through gene environmental interactions, are associated with cardiovascular diseases in multiple ethnic populations. 20470943 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Endothelial nitric oxide synthase (eNOS) gene variations have been linked to a higher risk for cardiovascular diseases (CVD) by unknown mechanisms. 20870316 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been associated with the pathogenesis of cardiovascular diseases, but few studies have evaluated the role of eNOS haplotypes on the risk and prognosis of heart failure (HF). 22290017 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. 25034973 2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Endothelial nitric oxide synthase gene polymorphisms in cardiovascular disease. 25189395 2014
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE A polymorphism of the ecNOS gene was recently shown to be associated with the development of cardiovascular disease. 10543322 1999
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE A single nucleotide polymorphism G894T within exon 7 of endothelial nitric oxide synthase (eNOS-7) gene, resulting in a replacement of glutamic acid by aspartic acid, has been studied as a putative candidate gene for cardiovascular diseases. 21623032 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE A single nucleotide polymorphism in the eNOS gene, where thymine (T) replaces guanine (G) at position 894 predicting substitution of glutamate for aspartate at codon 298 (Glu298Asp), has been associated with increased CVD risk due to effects on nitric oxide synthesis and subsequently vascular reactivity. 22689471 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease. 12065317 2002
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group LHGDN An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease. 12065317 2002
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE An insertion/deletion (I/D) polymorphism in the gene encoding the ACE and a single nucleotide exchange polymorphism (G894T) in the gene NOS3 encoding endothelial nitric oxide synthase have been associated with cardiovascular disorders. 12837457 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE An interaction between the E298D and T-786C polymorphisms in NOS3, cigarette smoking, and risk of incident coronary heart disease and ischemic stroke events appears to exist, suggesting a potential complex interplay between genetic and environmental factors and cardiovascular disease risk. 17108813 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE Another molecule, Sirtuin 1 (SIRT1), a histone/protein deacetylase, regulates endothelial nitric oxide synthase and is involved in different aspects of cardiovascular disease, aging and stress resistance. 30030618 2019
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE Asymmetric dimethylarginine (ADMA), an endothelial nitric oxide synthase inhibitor, plays a crucial role in the pathogenesis of various cardiovascular diseases associated with endothelial dysfunction. 30951718 2019
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Biomarkers of CVD risk, plasma fatty acid composition, and NOS3 single nucleotide polymorphism (SNP) genotype (rs11771443, rs1800783, rs1800779, rs1799983, rs3918227, and rs743507) were determined in 450 individuals with the MetS from the LIPGENE dietary intervention cohort. 20409549 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Both the thymidine to cytosine transition mutation (T(-786)-->C) in the promoter region and the missense mutation in the exon 7 coding region of the eNOS gene (G(894)-->T) have been associated with several cardiovascular disease states. 20350698 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE Cell-based eNOS gene therapy has both proangiogenic and antiatherogenic effects and should be further investigated for the development of efficient therapeutic neovascularization designed to treat ischemic cardiovascular disease. 21224043 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE Clear is that enhanced production of reactive oxygen species (ROS) and eNOS uncoupling are relatively important causes of reduced NO-bioactivity in cardiovascular disease states. 17584103 2007
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group CTD_human Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. 12947532 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group BEFREE Concomitant presence of CETP B1, NOS3 T and ANGPTL8 T alleles augments the risk of CVD and T2DM. 29973202 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 Biomarker group BEFREE Cytochrome P450 2D6 (CYP2D6) and endothelial nitric oxide synthase (eNOS) are important in the cardiovascular disease susceptibility and drug response. 31616043 2020
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 GeneticVariation group LHGDN Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics. 15565175 2005
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.500 AlteredExpression group BEFREE Expression of eNOS is altered in many types of cardiovascular disease, such as atherosclerosis, diabetes and hypertension. 18692595 2009