Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE We previously reported that the patients with cholesteryl ester transfer protein (CETP) deficiency (CETP-D) show marked changes in the size and lipid compositions of high-density lipoprotein (HDL) and that they are not protected from atherosclerotic cardiovascular diseases, despite increased serum HDL-cholesterol (HDL-C) levels. 30745272 2020
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Cholesteryl ester transfer protein (CETP) is an attractive therapeutic target for the prevention and treatment of cardiovascular diseases by lowering low-density lipoprotein cholesterol levels as well as raising high-density lipoprotein cholesterol levels in human plasma. 31780304 2020
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Thus, newer CETP inhibitors have now paramount importance to accelerate the drug discovery efforts in the field of cardiovascular disease (CVD). 30488780 2019
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Our results show that CETP is an important causal determinant of HDL and VLDL concentration and composition, which may imply that the CETP inhibitor anacetrapib decreased cardiovascular disease risk through specific reduction of small VLDL rather than LDL. 30420679 2019
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Do Cholesteryl Ester Transfer Protein Inhibitors Have a Role in the Treatment of Cardiovascular Disease? 30610681 2019
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 GeneticVariation group BEFREE Different therapies have been suggested and some are used to treat elevated lipoprotein(a) levels such as niacin, PCSK9 inhibitors, and CETP inhibitors; however, to date, no randomized controlled trial has demonstrated that lowering of lipoprotein(a) leads to lower risk of cardiovascular disease. 31111240 2019
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Cholesteryl ester transfer protein (CETP) inhibitor-mediated induction of HDL-cholesterol has no effect on the protection from cardiovascular disease (CVD). 31054484 2019
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Several trials to prevent cardiovascular disease by inhibiting cholesteryl ester transfer protein (CETP) have failed, except Randomized EValuation of the Effects of Anacetrapib through Lipid-modification. 29174438 2019
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression group BEFREE Inhibition of CETP lipid transfer activity has been shown to increase the plasma HDL-C levels and, therefore, became an effective strategy for combating cardiovascular diseases. 31418269 2019
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Cholesteryl ester transfer protein (CETP) belongs to the group of enzymes which inhibition have the application in the treatment of cardiovascular diseases. 31215331 2019
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 GeneticVariation group BEFREE We aimed to identify independent genetic determinants of circulating CETP (cholesteryl ester transfer protein) to assess causal effects of variation in CETP concentration on circulating lipid concentrations and cardiovascular disease risk. 29728394 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE The timeline is still long for CETP inhibitors to emerge from the treatment of CVD. 29424255 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression group BEFREE In the light of current knowledge, it seems reasonable to search for compounds that may decrease the activity of CETP, and thus reduce the incidence of cardiovascular disease. 29558025 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 GeneticVariation group BEFREE Concomitant presence of both, CETP B1 and NOS3 T allele, associated with increased risk of T2DM, CVD and CVD in T2DM by 8.36-, 6.33- and 7.87-fold, respectively, while concomitant presence of ANGPTL8 variant with either CETP B1 or NOS3 T allele was not associated with increased risk of T2DM or CVD. 29973202 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression group BEFREE To use genetic variants in the CETP gene to assess potential risks and benefits of lifelong lower CETP activity on CVD and other outcomes. 29141072 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression group BEFREE Efforts to raise HDL level via CETP inhibitors, Torcetrapib and Dalcetrapib, turned out to be disappointing in outcome studies despite substantial increases in HDL-C, suggesting that factors beyond HDL concentration may be responsible for the increased risks of CVD. 28828539 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Thus, glycans are an integral part of CETP, further studies on the CETP inhibition and treatment of CVD should fully consider the effect of glycans. 29726048 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 GeneticVariation group BEFREE Mendelian randomization studies indicate that most genetic variants that affect a range of pathways that increase plasma HDL-C levels are not usually associated with reduced risk of cardiovascular disease, with some exceptions, such as cholesteryl ester transfer protein variants. 28795686 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Expert opinion: In addition to our understanding of the relationships between CETP, HDL cholesterol and cardiovascular disease being incomplete, recent meta-analysis evidence suggests that increasing HDL cholesterol does not improve cardiovascular outcomes in subjects taking statins, and this may explain the failure of evacetrapib. 28799819 2017
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression group BEFREE Because low levels of plasma CETP are associated with increased plasma HDL-cholesterol, therapeutic inhibition of CETP activity is considered an attractive strategy for elevating plasma HDL-cholesterol, thereby hoping to reduce the risk of cardiovascular disease. 28767652 2017
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 GeneticVariation group BEFREE High levels of plasma high-density lipoprotein-cholesterol (HDL-C) are inversely associated with the risk of atherosclerosis and other cardiovascular diseases; thus, pharmacological inhibition of cholesteryl ester transfer protein (CETP) is considered to be a therapeutic method of raising HDL-C levels. 29317793 2017
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Therefore, there is a great interest in developing new cholesteryl ester transfer protein (CETP) inhibitors capable of raising HDL as a novel approach for the prevention of cardiovascular disease. 29112287 2017
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression group BEFREE CETP (cholesteryl ester transfer protein) plays an important role in lipoprotein metabolism; however, whether inhibition of CETP activity can prevent cardiovascular disease remains controversial. 28428219 2017
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Cholesteryl ester transfer protein (CETP) has been identified as a potential target for cardiovascular disease (CVD) for its important role in the reverse cholesteryl transfer (RCT) process. 29112169 2017
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker group BEFREE Cholesteryl ester transfer protein (CETP) inhibitors are a new class of therapeutics for dyslipidemia that simultaneously improve two major cardiovascular disease (CVD) risk factors: elevated low-density lipoprotein (LDL) cholesterol and decreased high-density lipoprotein (HDL) cholesterol. 28911944 2017