Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Intercellular adhesion molecule-1 (ICAM-1) is a proinflammatory and proatherogenic cytokine which is associated with atherosclerosis, insulin resistance, and cardiovascular disease (CVD). 31629408 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Inhibition of ICAM-1 may represent a new therapeutic approach for hypertrophic heart diseases.<b>NEW & NOTEWORTHY</b> Leukocyte adhesion to vascular endothelium is a critical step in cardiovascular diseases. 31729904 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Adhesion molecules, including soluble E-selectin (sE-selectin), intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1), are associated with incident CVD. 30653588 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression group BEFREE The study indicated that synbiotic supplementation reduced serum ICAM-1 level, which is a risk factor for cardiovascular diseases in HD patients, but has no effect on the necrosis marker. 30293208 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE The present study included 27,071 participants (mean age = 54.5 years) in the Women's Health Study who were free of cancer and cardiovascular disease at enrollment (1992-1995), with baseline measures of 4 inflammatory biomarkers: high-sensitivity C-reactive protein, fibrinogen, N-acetyl side-chains of acute phase proteins, and soluble intercellular adhesion molecule-1. 28641369 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE To better understand the early phases of vascular deterioration in a young, healthy population, we investigated, cross-sectionally, whether biomarkers of endothelial function (intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and von Willebrand factor antigen (vWF<sub>ag</sub>)) are associated with IGF-1 in a healthy study population forming part of the larger African Prospective study on the Early Detection and Identification of Cardiovascular diseases and Hypertension (African-PREDICT). 29936324 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation group BEFREE Expression of mediators of cholesterol transport, namely the lectin-like oxidized low-density lipoprotein receptor (LOX)-1 and ATP-binding cassette transporter (ABCA)-1, inflammatory markers tumor necrosis factor (TNF)-α and interleukin (IL)-1β/IL-6, nuclear-factor kappa-light-chain-enhancer of activated B cells (NF-κB), intracellular/vascular adhesion molecule(s) (VCAM-1, ICAM-1), and miRNAs (miR-221/-21/-1), associated with cardiovascular disease (CVD), were analyzed in cardiac tissue and coronary vasculature. 30081225 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Soluble cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1, E-selectin, and P-selectin, have been suggested to be associated with cardiovascular disease (CVD) risk; however, the nature and magnitude of the association between VCAM-1 and CVD risk is uncertain. 28202840 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Reduction in ICAM-1 and MCP-1 in human endothelium is an important extent of the use of this drug for treatment of cardiovascular diseases, and NO has an important role in this process. 28371087 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation group BEFREE Furthermore, parameters that correlated with the levels of indoxyl sulfate (von Willebrand factor, soluble urokinase-type plasminogen activator receptor, soluble intercellular adhesion molecule-1) were positively associated with the prevalence of cardiovascular disease in a CKD patients. 28122514 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation group BEFREE Of the 170 SNPs tested, multiplicative interactions between well-water arsenic and two SNPs, rs281432 in ICAM1 (padj = 0.0002) and rs3176867 in VCAM1 (padj = 0.035), were significant for CVD after adjustment for multiple testing. 25575156 2015
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group CTD_human Of the 170 SNPs tested, multiplicative interactions between well-water arsenic and two SNPs, rs281432 in ICAM1 (padj = 0.0002) and rs3176867 in VCAM1 (padj = 0.035), were significant for CVD after adjustment for multiple testing. 25575156 2015
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Furthermore, a significant inverse correlation between the concentrations of the inflammatory CVD risk markers ICAM-1, E-selectin and P-selectin and the degree of ACE promoter methylation in MD patients could be demonstrated (p = 0.01 - 0.04). 22808171 2012
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression group BEFREE Linoleic acid (LA), a dietary unsaturated fatty acid, has been known to increase the expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) through the activation of nuclear factor-kappa B. Rho/Rho-kinase (ROCK) pathway mediates various cellular functions related to cardiovascular disease and affects the expression of ICAM-1. 22124782 2012
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation group BEFREE The intercellular adhesion molecule-1 (ICAM-1) gene polymorphism K469E in end-stage renal disease patients with cardiovascular disease. 22609477 2012
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression group LHGDN Differential effect of soluble intercellular adhesion molecule-1 on the progression of atherosclerosis as compared to arterial thrombosis: a prospective analysis of the Women's Health Study. 17640650 2008
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation group BEFREE The objective of this study was to examine the association of 2 nonsynonymous intercellular adhesion molecule 1 (ICAM1) gene variants (Lys56Met and Gly241Arg) with baseline plasma soluble ICAM1 concentrations and with risk of total and selected cardiovascular disease (CVD) events in a prospective cohort of 23 014 apparently healthy white American women followed for 10 years. 17962597 2007
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE We investigated the role of four thrombosis genes: coagulation factor V (F5), intercellular adhesion molecule 1 (ICAM1), protein C (PROC), and thrombomodulin (THBD) in cardiovascular diseases. 17677000 2007
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group CTD_human Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. 16332659 2005
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation group BEFREE We examined the association of the ICAM-1 K469E gene variant and plasma sICAM-1 with coronary artery calcification (CAC) in 632 asymptomatic subjects, recruited on the basis of a family history of premature cardiovascular disease. 15682683 2004
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Inflammation variables (C-reactive protein [CRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]) have been identified as risk factors for cardiovascular disease. 15345506 2004
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1) are involved in the pathogenetic mechanisms responsible for several ischemic cardiovascular disorders, including cerebral ischemia. 12637697 2003
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Intracellular adhesion molecule-1 (ICAM-1), a cellular adhesion molecule that mediates the interaction of activated endothelial cells with leukocytes, is involved in various inflammatory and cardiovascular disorders. 12939654 2003
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation group BEFREE This is the first study documenting a role of the ICAM-1 gene polymorphism in the pathogenesis of a cardiovascular disease, such as PAOD. 12192299 2002
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker group BEFREE Intercellular adhesion molecule-1 (ICAM-1) is implicated in the pathogenesis of ischemic cardiovascular disorders, including cerebral ischemia. 12095649 2002