Self-reported Coloured South African participants, with a history of carpal tunnel release surgery (CTS, n=103) and matched control (CON, n=150) participants without any reported history of CTS symptoms were genotyped for COL1A1 rs1800012 (G/T), COL11A1rs3753841 (T/C), COL11A1rs1676486 (C/T), COL11A2 rs1799907 (T/A) and COL12A1 rs970547 (A/G).