Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1289
Gene Symbol: COL5A1
COL5A1
0.020 GeneticVariation disease BEFREE One hundred and three self-reported coloured participants, with a history of carpal tunnel release surgery (CTS) and 150 matched control (CON) participants without any reported history of CTS symptoms were genotyped for the COL5A1 rs13946 (C/T), rs14774622 (C/T)/rs55748801 (G/A) (W/M where W = CG), rs12722 (C/T) and rs71746744 (-/AGGG) variants. 24966028 2015
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.010 GeneticVariation disease BEFREE Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and disability, but not widespread pressure pain sensitivity, in women with carpal Tunnel syndrome. 24077209 2014
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.010 AlteredExpression disease BEFREE We found that CTS significantly inhibited the IL-1β-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-3, MMP-13, and ADAMTS-5. 28666239 2017
Entrez Id: 1442
Gene Symbol: CSH1
CSH1
0.010 Biomarker disease BEFREE Patients with DM and CTS had a slightly enlarged median nerve CSA than did patients with only CTS, but the difference was not statistically significant (0.52 mm<sup>2</sup>, 95% CI - 0.54 to 1.59). 30805796 2019
Entrez Id: 1443
Gene Symbol: CSH2
CSH2
0.010 Biomarker disease BEFREE Patients with DM and CTS had a slightly enlarged median nerve CSA than did patients with only CTS, but the difference was not statistically significant (0.52 mm<sup>2</sup>, 95% CI - 0.54 to 1.59). 30805796 2019
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
0.020 Biomarker disease BEFREE Correction to: Aromatase inhibitor-induced carpal tunnel syndrome: prevalence in daily practice. 30535957 2019
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
0.020 GeneticVariation disease BEFREE Prospective evaluation of finger two-point discrimination and carpal tunnel syndrome among women with breast cancer receiving adjuvant aromatase inhibitor therapy. 31079282 2019
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS
0.010 Biomarker disease BEFREE METHODS The authors utilized the PearlDiver database to identify the number of individuals with CTS in the Medicare patient population, and then utilized CPT codes to identify which individuals underwent surgical management. 29712517 2018
Entrez Id: 2202
Gene Symbol: EFEMP1
EFEMP1
0.100 GeneticVariation disease GWASCAT A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. 30833571 2019
Entrez Id: 2004
Gene Symbol: ELK3
ELK3
0.010 Biomarker disease BEFREE We used multivariable Cox proportional hazards regression models to describe exposure-disease associations for incident CTS for individually observed physical exposures and JEM exposures from O*NET. 29599164 2018
Entrez Id: 2047
Gene Symbol: EPHB1
EPHB1
0.010 Biomarker disease BEFREE We used multivariable Cox proportional hazards regression models to describe exposure-disease associations for incident CTS for individually observed physical exposures and JEM exposures from O*NET. 29599164 2018
Entrez Id: 1161
Gene Symbol: ERCC8
ERCC8
0.010 Biomarker disease BEFREE Patients with DM and CTS had a slightly enlarged median nerve CSA than did patients with only CTS, but the difference was not statistically significant (0.52 mm<sup>2</sup>, 95% CI - 0.54 to 1.59). 30805796 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.010 Biomarker disease LHGDN Estrogen and progesterone receptors in carpal tunnel syndrome. 17951080 2008
Entrez Id: 2191
Gene Symbol: FAP
FAP
0.010 GeneticVariation disease BEFREE Although concomitant lesions in the ulnar nerve entrapment site at the wrist cannot be excluded, these findings indicate that CTS is not the sole distinctive feature in the majority of FAP ATTR Val30Met patients. 19626479 2009
Entrez Id: 2690
Gene Symbol: GHR
GHR
0.010 AlteredExpression disease BEFREE Significantly higher GHR gene expression levels in tall subjects suggests a sensitization of the GHR-IGF system leading to overgrowth in CTS. 28301320 2017
Entrez Id: 373156
Gene Symbol: GSTK1
GSTK1
0.010 GeneticVariation disease BEFREE We aimed to clarify the associations between glutathione S-transferase (GST)M1, GSTT1 and GSTP1-Ile105Val polymorphisms and CTS. 25566970 2016
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.010 GeneticVariation disease BEFREE The GSTM1 null genotype may be related with the development of CTS, whereas the Val allele of GSTP1-Ile105Val polymorphism may be associated with worse functional and clinical status in CTS. 25566970 2016
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.010 GeneticVariation disease BEFREE We aimed to clarify the associations between glutathione S-transferase (GST)M1, GSTT1 and GSTP1-Ile105Val polymorphisms and CTS. 25566970 2016
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
0.020 GeneticVariation disease BEFREE We aimed to clarify the associations between glutathione S-transferase (GST)M1, GSTT1 and GSTP1-Ile105Val polymorphisms and CTS. 25566970 2016
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
0.020 GeneticVariation disease BEFREE The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers. 15018031 2004
Entrez Id: 10866
Gene Symbol: HCP5
HCP5
0.100 GeneticVariation disease GWASCAT A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. 30833571 2019
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
0.010 AlteredExpression disease BEFREE An Agilent miRNA microarray was used to profile miRNAs in the CTS-treated BMSCs and 3D-cultured control BMSCs. miR-365 was shown to interact with HDAC4 mRNA through a luciferase reporter assay. 31276691 2019
Entrez Id: 3113
Gene Symbol: HLA-DPA1
HLA-DPA1
0.010 GeneticVariation disease BEFREE The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers. 15018031 2004
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.010 GeneticVariation disease BEFREE The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers. 15018031 2004
Entrez Id: 3125
Gene Symbol: HLA-DRB3
HLA-DRB3
0.010 GeneticVariation disease BEFREE The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers. 15018031 2004