|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Celiac disease (CD) patients usually express a DQ2 heterodimer, whose chains DQalpha1*0501/DQbeta1*0201, are encoded by the genes HLA-DQA1*0501 and DQB1*0201, respectively.
|
10398807 |
1999 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Celiac disease (CD) is sustained by abnormal intestinal mucosal T-cell response to gluten and it is strongly associated with HLA class II molecules encoded by DQA1*0501/DQB1*02 (DQ2) or DQA1*03/DQB1*0302 (DQ8).
|
15781184 |
2005 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
celiac disease is associated with the HLA class II alleles: DQA1*05-DQB1*02 and DQB1*0302.
|
24274444 |
2013 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Celiac disease (CD) is associated with tissue transglutaminase autoantibodies (tTGAs) in individuals carrying the human leukocyte antigen (HLA) risk haplotypes DQA1*05:01-DQB1*02:01 (DQ2) and/or DQA1*03:01-DQB1*03:02 (DQ8).
|
26301618 |
2016 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DQA1 and DQB1 molecular typing was performed in 218 adult CD patients (169 with uncomplicated CD, 27 with complicated CD, and 22 with potential CD) and 224 healthy stem cell donors.
|
21694611 |
2012 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA DQA1*05 and DQB1*02 alleles encoding the DQ2.5 molecule and HLA DQA1*03 and DQB1*03 alleles encoding DQ8 molecules are strongly associated with celiac disease (CD) and type 1 diabetes (T1D), two common autoimmune diseases (AD).
|
31331105 |
2019 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DQA1*0101 allele appears significantly in DS-CD + patients and deserves to be searched for in a larger sample to assess its meaning in the DS-CD association.
|
8890082 |
1996 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on HLA-DR3 haplotypes: analysis of transmission from homozygous parents.
|
12590980 |
2003 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A gene dosage effect of the DQA1*0501/DQB1*0201 allelic combination influences the clinical heterogeneity of celiac disease.
|
7928444 |
1994 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
|
17558408 |
2007 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
|
17558408 |
2007 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
A high prevalence of HLA-DQA1* and -DQB1* susceptibility haplotypes for CD was observed both in EMA-negative diabetics and in those with associated CD.
|
15174785 |
2004 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A new DQA1 allele (DQA1*0510) in a Spanish celiac disease patient.
|
20047644 |
2010 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
A one-step real-time PCR assay for detection of DQA1*05, DQB1*02 and DQB1*0302 to aid diagnosis of celiac disease.
|
17020762 |
2006 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An association with a 15 base-pair deletion in exon 12 of PRSS16 was found on the DRB1*03-DQA1*0501-DQB1*0201 haplotype for both T1D and CD, but it could not explain the more pronounced disease associations observed at marker D6S2223.
|
17584581 |
2007 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An independence test in DR3-DQ2 haplotype found that association with CD was attributable to the whole haplotype, but for DR7-DQ2 was secondary to DQB1/DQA1.
|
19254257 |
2009 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
As CD susceptibility has been shown to be strongly associated with the HLA alleles DQA1*0501 and DQB1*0201 (together encoding the DQ2 heterodimer) and DRB1*04 (associated with the DQ8 heterodimer), our aim was to investigate whether HLA genotyping might be useful in the identification of 1st-degree relatives of CD patients who do not need further screening for CD.
|
17060123 |
2006 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As expected, all CD patients had at least one of the CD-associated alleles, and the highest CD risk was indicated by the presence of the HLA-DQ2.5 heterodimer (HLA-DQA1*05-DQB1*02) with HLA-DQB1*02 in homozygosity.
|
25413104 |
2014 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Asp57-negative HLA DQ beta chain and DQA1*0501 allele are essential for the onset of DQw2-positive and DQw2-negative coeliac disease.
|
8419077 |
1993 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk.
|
26010309 |
2015 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Because of rarely reported cases of CD/rhabdomyolysis, anti-tissue transglutaminase (tTG) antibodies were measured and found positive (IgA 34 U/mL, unv <9).HLA typing was DQA1 05:02, DQB1 03:02.
|
28606713 |
2018 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Besides the well known involvement of the HLA class II histocompatibility antigen (HLA)-DQ2.5 and -DQ8 heterodimers (encoded by particular combinations of the HLA-DQA1 and -DQB1 gene) in CD and the minor contribution of the CTLA-4 gene, recently the myosin IXB (MYO9B) gene has also been found to be genetically associated.
|
17438672 |
2006 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Both HLA alleles DQA1*05 and DQB1*02 are associated with a greatly increased risk of CD, although the latter has the greater effect.
|
17919990 |
2007 |