|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A new DQA1 allele (DQA1*0510) in a Spanish celiac disease patient.
|
20047644 |
2010 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
High-resolution, sequence-specific oligonucleotide probe typing with 35 DQA1-specific and 37 DQB1-specific probes of DNA from more than 10,000 subjects was used to stratify risk of CD in an at-risk U.S. population.
|
19500688 |
2009 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the HLA DRB1, DQB1 and DQA1 polymorphism in Tunisian children with typical form of coeliac disease (CD) in comparison with those from mass screening (atypical and silent CD).
|
19474744 |
2009 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Certain HLA heterodimers, namely DQ2 (encoded by the DQA1*05 and DQB1*02 alleles) and DQ8 (DQA1*03 and DQB1*0302), are necessary for the development of celiac disease.
|
19255754 |
2009 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An independence test in DR3-DQ2 haplotype found that association with CD was attributable to the whole haplotype, but for DR7-DQ2 was secondary to DQB1/DQA1.
|
19254257 |
2009 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We propose the use of the DQ-CD Typing kit that allows identification of the HLA class II alleles (DQA1*0201,*03,*05, DQB1*02,*0302, DRB1*03,*04,*07) selected to be informative in the CD risk evaluation and of a second kit, namely DQ-CD Zygosis, for DQB1*02 homozygosity determination.
|
18076355 |
2008 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our tagging approach exploits linkage disequilibrium between single nucleotide polymorphism (SNPs) and the CD-associated HLA risk factors DQ2.5 and DQ8 that indicate direct risk, and DQA1*0201/DQB1*0202 (DQ2.2) and DQA1*0505/DQB1*0301 (DQ7) that attribute to the risk of DQ2.5 to CD.
|
18509540 |
2008 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
LHGDN |
HLA-DQ and susceptibility to celiac disease: evidence for gender differences and parent-of-origin effects.
|
18177450 |
2008 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
|
17558408 |
2007 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Both HLA alleles DQA1*05 and DQB1*02 are associated with a greatly increased risk of CD, although the latter has the greater effect.
|
17919990 |
2007 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
|
17558408 |
2007 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An association with a 15 base-pair deletion in exon 12 of PRSS16 was found on the DRB1*03-DQA1*0501-DQB1*0201 haplotype for both T1D and CD, but it could not explain the more pronounced disease associations observed at marker D6S2223.
|
17584581 |
2007 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic predisposition to celiac disease (CD) is determined primarily by the human leukocyte antigen (HLA) genes (CELIAC1 region; 6p21), although many loci are involved in disease susceptibility.
|
17767555 |
2007 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the DQA1*0501 allele did not have a significant association with the severity of CD.
|
16484124 |
2006 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
HLA DQA1*0501 and DQB1*02 in Cuban celiac patients.
|
16916661 |
2006 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
As CD susceptibility has been shown to be strongly associated with the HLA alleles DQA1*0501 and DQB1*0201 (together encoding the DQ2 heterodimer) and DRB1*04 (associated with the DQ8 heterodimer), our aim was to investigate whether HLA genotyping might be useful in the identification of 1st-degree relatives of CD patients who do not need further screening for CD.
|
17060123 |
2006 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that the risk of CD in children with type 1 diabetes is significantly modified both by the presence of HLA-DQB1*02-DQA1*05 and by a variant of another gene within the major histocompatibility complex, the TNF -308A.
|
16567828 |
2006 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Three non-biopsied DS patients had also most probably CD because DQA1*0501/DQB1*0201 and IgA anti-tTG (EMA) were detected.
|
16552815 |
2006 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
LHGDN |
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.
|
16878175 |
2006 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
A one-step real-time PCR assay for detection of DQA1*05, DQB1*02 and DQB1*0302 to aid diagnosis of celiac disease.
|
17020762 |
2006 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Individuals with CD or TgAA+ were enriched for DRB1*0301-DQA1*0501-DQB1*0201, a haplotype previously reported as high risk for CD.
|
17145374 |
2006 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Besides the well known involvement of the HLA class II histocompatibility antigen (HLA)-DQ2.5 and -DQ8 heterodimers (encoded by particular combinations of the HLA-DQA1 and -DQB1 gene) in CD and the minor contribution of the CTLA-4 gene, recently the myosin IXB (MYO9B) gene has also been found to be genetically associated.
|
17438672 |
2006 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Celiac disease (CD) is sustained by abnormal intestinal mucosal T-cell response to gluten and it is strongly associated with HLA class II molecules encoded by DQA1*0501/DQB1*02 (DQ2) or DQA1*03/DQB1*0302 (DQ8).
|
15781184 |
2005 |