|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The DRB1 *03:01- DQB1 *02:01- DQA1 *05:01/ DRB1 *04- DQB1 *03:02- DQA1 *03 haplotype combination, encoding DQ2.5 and DQ8 molecules, was equally frequent among patients with both T1D and CeD (52.6%) and T1D patients (46.8%) but significantly lower in CeD patients (9.5%).
|
28247576 |
2017 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The data also revealed 2 distinct celiac disease risk DR3-DQA1*05:01-DQB*02:01 haplotypes distinguished by either the DRB3*01:01:02 or DRB3*02:02:01 alleles, indicating that different DRB1*03:01-DQB1*02:01 haplotypes confer different risk for celiac disease.
|
28585303 |
2017 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate a possible correlation between the HLA-DQA1 and HLA-DQB1 genetic markers and clinical features of celiac disease.
|
12050583 |
2002 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The DQA1*0501 and DQB1*0201 alleles (hereafter DQ2) confer genetic susceptibility to celiac disease (CD).
|
9129973 |
1997 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The HLA DQA1 DQB1 high-risk genotypes associated with celiac disease are similar in these Bedouin families with CD to what is observed in Northern and Southern Europeans.
|
12039527 |
2002 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The HLA DQA1 DQB1 high-risk genotypes associated with celiac disease are similar in these Bedouin families with CD to what is observed in Northern and Southern Europeans.
|
12039527 |
2002 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Susceptibility to coeliac disease is associated with a particular HLA-DQ alpha beta heterodimer encoded by the DQA1*0501 and DQB1*02 genes.
|
9587738 |
1998 |
|
HLA-DQA1
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Polymorphism of the 5' flanking region of the HLA-DQA1 gene in coeliac disease.
|
9098408 |
1993 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Patients with celiac disease (CD) lacking both human leukocyte antigen (HLA)-DQ2.5 in cis (DQA1*05:01, DQB1*02:01) or trans (DQA1*05:05, DQB1*02:02) configuration and HLA-DQ8 (DQA1*03:01, DQB1*03:02) are considered to be rare.
|
23085892 |
2013 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our tagging approach exploits linkage disequilibrium between single nucleotide polymorphism (SNPs) and the CD-associated HLA risk factors DQ2.5 and DQ8 that indicate direct risk, and DQA1*0201/DQB1*0202 (DQ2.2) and DQA1*0505/DQB1*0301 (DQ7) that attribute to the risk of DQ2.5 to CD.
|
18509540 |
2008 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that in addition to the DQ2 heterodimer, the other major risk alleles for CD are DR4 DQ8, and either DQA1*0501 or DQB1*02 alone.
|
9548076 |
1998 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
One patient showed a positivity only for HLA-DQ2.2 (encoded by DQA1*02 & B1*02).Our study showed that the genetic risk for CD was present in more than one-third of the cases without a confirmed diagnosis of CD.
|
28514313 |
2017 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of CD patients, 92% (50% DR3 and 42% DR5,7) compared to 18% of the controls carry both DQA1*0501 and DQB1*0201 alleles, so that the combination confers an RR of 52, higher than both the risks of the single alleles (DQA1*0501 RR = 19, DQB1*0201 RR = 30), confirming the primary role of the dimer in determining genetic predisposition to CD both in DR3 and in DR5,7 subjects.
|
1563982 |
1992 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the association with CD became stronger when B*08(B*08-DQA*0501-DQB1*0201-DRB1*0301, P = 5.07 x 10(-12)) was present in the DRB1*0301-DQB1*0201-DQA1*0501 (P = 5.00 x 10(-10)) extended haplotype.
|
20492597 |
2010 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
MHC class I chain related gene A (MICA) modulates the development of coeliac disease in patients with the high risk heterodimer DQA1*0501/DQB1*0201.
|
11839711 |
2002 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Less frequently, CD occurs in individuals positive for the DQ2.x heterodimers (DQA1≠*05 and DQB1*02) and very rarely in patients negative for these DQ predisposing markers.
|
23050549 |
2012 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that celiac disease (CD) is strongly associated with the HLA-DQ2 alleles DQA1*0501 and DQB1*0201.
|
15386476 |
2004 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Individuals with CD or TgAA+ were enriched for DRB1*0301-DQA1*0501-DQB1*0201, a haplotype previously reported as high risk for CD.
|
17145374 |
2006 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Individuals homozygous for DQ2 or heterozygous for DQA1*05-DQB1*02/DQA1*0201-DQB1*02 were found to be at five-fold increased risk for development of coeliac disease (P<10(-8)).
|
15014431 |
2004 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this chapter we will present the principal technical methods to genotype the HLA-DQA1* and -DQB1* alleles associated with celiac disease (CD), corresponding to the serological heterodimers HLA-DQ2 and -DQ8.
|
26498615 |
2015 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we aimed to evaluate the frequency of polymorphisms that affects the structure of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), with levels being dependent on the amount of oxidative stress and whether or not there is an association with the mutations DQA1*0501, DQB1*0201, and DRB1*04 that are frequently reported for CD.
|
24634124 |
2014 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In patients with LADA similarly to type 1 genotype DQA1*0301 seems to CONFER susceptibility to thyroid autoimmunity, and DQB1*0201 to celiac disease.
|
26884287 |
2016 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In dermatitis herpetiformis, as in celiac disease, the strongest association of disease was with the DQ subregion alleles DQB1*0201 and DQA1*0501 that are linked to the DRB1*0301 allele.
|
1919044 |
1991 |