|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this chapter we will present the principal technical methods to genotype the HLA-DQA1* and -DQB1* alleles associated with celiac disease (CD), corresponding to the serological heterodimers HLA-DQ2 and -DQ8.
|
26498615 |
2015 |
|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As expected, all CD patients had at least one of the CD-associated alleles, and the highest CD risk was indicated by the presence of the HLA-DQ2.5 heterodimer (HLA-DQA1*05-DQB1*02) with HLA-DQB1*02 in homozygosity.
|
25413104 |
2014 |
|
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest that clinically suspected individuals for CD and first-degree relatives of patients with CD to be screened for HLA-DQB*0201 and DQB*0302 alleles for possible early diagnosis and treatments.
|
24917237 |
2014 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As expected, all CD patients had at least one of the CD-associated alleles, and the highest CD risk was indicated by the presence of the HLA-DQ2.5 heterodimer (HLA-DQA1*05-DQB1*02) with HLA-DQB1*02 in homozygosity.
|
25413104 |
2014 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we aimed to evaluate the frequency of polymorphisms that affects the structure of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), with levels being dependent on the amount of oxidative stress and whether or not there is an association with the mutations DQA1*0501, DQB1*0201, and DRB1*04 that are frequently reported for CD.
|
24634124 |
2014 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To predict the HLA-DQA1 and -DQB1 genes, we used six previously reported HLA-tagging single nucleotide polymorphism to determine HLA genotypes in 59 Iranian patients with 'biopsy-confirmed' CD and in 151 healthy Iranian individuals.
|
24876751 |
2014 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
celiac disease is associated with the HLA class II alleles: DQA1*05-DQB1*02 and DQB1*0302.
|
24274444 |
2013 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
For the development of classic gluten-sensitive CD a certain HLA haplotype involving the loci DQA1* and DQB1* and encoding two different HLA DQ heterodimers is the prerequisite.
|
23609110 |
2013 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The risk for celiac disease (CD) is clearly related to specific HLA DQA1 and DQB1 alleles, but HLA -typing is often considered too costly for frequent use.Here we present a method using sequence-specific primed PCR (PCR-SSP) for HLA-DR-DQ genotyping optimized for capillary electrophoresis on Applied Biosystems 3130xl Genetic Analyzer.
|
22976110 |
2013 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Patients with celiac disease (CD) lacking both human leukocyte antigen (HLA)-DQ2.5 in cis (DQA1*05:01, DQB1*02:01) or trans (DQA1*05:05, DQB1*02:02) configuration and HLA-DQ8 (DQA1*03:01, DQB1*03:02) are considered to be rare.
|
23085892 |
2013 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Less frequently, CD occurs in individuals positive for the DQ2.x heterodimers (DQA1≠*05 and DQB1*02) and very rarely in patients negative for these DQ predisposing markers.
|
23050549 |
2012 |
|
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing.
|
23050549 |
2012 |
|
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, multivariate analysis demonstrated that patients with potential CD have a higher frequency of both HLA-DQB1*0302 and HLA-DQB1*0603 alleles and a reduced frequency of DQB1*02 homozygosity compared with patients with uncomplicated and complicated CD.
|
21694611 |
2012 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DQA1 and DQB1 molecular typing was performed in 218 adult CD patients (169 with uncomplicated CD, 27 with complicated CD, and 22 with potential CD) and 224 healthy stem cell donors.
|
21694611 |
2012 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study confirms the existing data and provides additional evidence supporting a strong genetic predisposition for CD associated with the class II alleles DQB1*02 and DQA1*05 encoding the serological specificity DQ2.
|
23041663 |
2012 |
|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Higher frequencies for HLA-DQB1*02:01 (40.25 vs. 9.58%, P < 0.001) and DQB1*02:02 (20.34 vs. 5.42%, P < 0.001) were observed in patients with CD, whereas HLA-DQB1*03:01 (16.53 vs. 30.42%, P < 0.001), DQB1*05:01 (0.85 vs. 10%, P < 0.001), and DQB1*05:02 (5.51 vs. 17.92%, P < 0.001) were significantly lower, as compared with the controls.
|
23041663 |
2012 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively reviewed the medical records of 127 consecutive cases of adult-onset celiac disease evaluated at a single United States center to determine the distribution of the associated human leukocyte antigen DQA1 and DQB1 alleles.
|
21292306 |
2011 |
|
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The proportion of clinically undetected celiac disease may be particularly high among 3-year-old children with HLA-DQB1*02 and DQB1*0302 in Sweden, where these 2 HLA-risk alleles frequently occur.
|
19915493 |
2010 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the association with CD became stronger when B*08(B*08-DQA*0501-DQB1*0201-DRB1*0301, P = 5.07 x 10(-12)) was present in the DRB1*0301-DQB1*0201-DQA1*0501 (P = 5.00 x 10(-10)) extended haplotype.
|
20492597 |
2010 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A new DQA1 allele (DQA1*0510) in a Spanish celiac disease patient.
|
20047644 |
2010 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
High-resolution, sequence-specific oligonucleotide probe typing with 35 DQA1-specific and 37 DQB1-specific probes of DNA from more than 10,000 subjects was used to stratify risk of CD in an at-risk U.S. population.
|
19500688 |
2009 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the HLA DRB1, DQB1 and DQA1 polymorphism in Tunisian children with typical form of coeliac disease (CD) in comparison with those from mass screening (atypical and silent CD).
|
19474744 |
2009 |
|
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Certain HLA heterodimers, namely DQ2 (encoded by the DQA1*05 and DQB1*02 alleles) and DQ8 (DQA1*03 and DQB1*0302), are necessary for the development of celiac disease.
|
19255754 |
2009 |