Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 Biomarker disease BEFREE Duodenal tissues from patients with untreated celiac disease had increased levels of mRNAs encoding IL15 receptor subunit alpha (IL15RA) and IL21 compared with tissues from patients with potential celiac disease and controls. 31622625 2020
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 AlteredExpression disease BEFREE Expression levels of the IL21 and Trx genes were not significantly modulated in the CD group compared to the control group, whereas the IL17A gene in CD patients was transcribed at significantly higher levels among the CD group. 30183349 2018
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 AlteredExpression disease BEFREE In children with coeliac disease, the genes coding for pro-inflammatory cytokines IFN-γ, IL-11, IL-18, and IL-21 were significantly overexpressed, suggesting the possible importance of these cytokines in the relationships between coeliac disease and dental disorders. 26440733 2016
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease BEFREE Certain gene polymorphisms of IL2/IL21 (rs6822844 and rs6840978) and SH2B3 (rs3184504) may influence susceptibility to CD, although the effects remain unclear. 26535636 2015
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 Biomarker disease BEFREE These results demonstrate that an IL-17A-independent increase in IL-21 production by CD4(+) T cells is characteristic of pediatric CD. 23571506 2013
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 Biomarker disease BEFREE IL-21 was highly produced by CD4+ and CD4+/CD8+ IELs and LPLs in active CD. 22785229 2013
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease BEFREE Based on this review, we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia in 223 families, 108 unrelated individuals with schizophrenia and 120 controls. 21688385 2011
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease BEFREE Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk. 22077623 2011
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 AlteredExpression disease BEFREE Blockade of IL-21 activity by a neutralizing IL-21 Ab reduced IL-17A expression in cultures of active CD and peptic-tryptic digest of gliadin-treated CD biopsy specimens. 20061410 2010
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 Biomarker disease BEFREE Recent genome-wide association studies have identified 1q31 (RGS1), 2q11-12 (IL18RAP), 3p21 (CCR1/CCR3/CCR2), 3q25-26 (IL12A/SCHIP1), 3q28 (LPP), 4q27 (IL2/IL21), 6q25 (TAGAP) and 12q24 (SH2B3) as susceptibility regions for coeliac disease (CD). 19693089 2010
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease BEFREE Common variation in IL2/IL21, RGS1, IL12A/SCHIP and SH2B3 was associated with susceptibility to CD in our Italian cohort. 18805825 2009
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease BEFREE Five SNPs strongly associated with celiac disease within the KIAA1109/TENR/IL2/IL21 linkage disequilibrium block on chromosome 4q27 and one coding SNP within the IL21 gene were analyzed in a large German IBD cohort. 19455118 2009
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease BEFREE The four single nucleotide polymorphisms (SNPs) in the IL2/IL21 locus most associated with coeliac disease were genotyped in 1590 subjects with IBD and 929 controls from The Netherlands, and then replicated in a North American cohort (2387 cases and 1266 controls) and an Italian cohort (805 cases and 421 controls), yielding a total of 4782 cases (3194 UC, 1588 CD) and 2616 controls. 19201773 2009
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 Biomarker disease BEFREE To examine whether interleukin 21 (IL21), a cytokine that regulates T cell activation, has a role in CD. 17965065 2008
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease BEFREE Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. 18311140 2008
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 Biomarker disease BEFREE In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region. 18418394 2008
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 Biomarker disease BEFREE This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis). 18369459 2008
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease BEFREE We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. 17558408 2007
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease BEFREE Recently, association of celiac disease with common single-nucleotide polymorphism (SNP) variants in an extensive linkage-disequilibrium block of 480 kb containing the KIAA1109, Tenr, IL2, and IL21 genes has been demonstrated in three independent populations (rs6822844P combined=1.3 x 10(-14)). 17999365 2007
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 GeneticVariation disease LHGDN We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. 17558408 2007
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.400 Biomarker disease CTD_human We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. 17558408 2007