Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5 		0.210 Biomarker disease RGD Zileuton reduces inflammatory reaction and brain damage following permanent cerebral ischemia in rats. 20204486 2010
Entrez Id: 285
Gene Symbol: ANGPT2
ANGPT2 		0.210 Biomarker disease BEFREE Lack of the Mas receptor may have a protective effect against chronic brain ischemia when the Ang II type 2 receptor exists. 29431106 2018
Entrez Id: 285
Gene Symbol: ANGPT2
ANGPT2 		0.210 Biomarker disease RGD The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats. 17494864 2007
Entrez Id: 301
Gene Symbol: ANXA1
ANXA1 		0.200 Biomarker disease RGD Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain. 1830327 1991
Entrez Id: 317
Gene Symbol: APAF1
APAF1 		0.200 Biomarker disease RGD Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia. 17640469 2007
Entrez Id: 328
Gene Symbol: APEX1
APEX1 		0.200 Biomarker disease RGD Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons. 9030714 1997
Entrez Id: 8862
Gene Symbol: APLN
APLN 		0.010 Biomarker disease BEFREE Apelin-13 might protect oxidative stress-induced hair cell damage was raised considering other oxidative stress-induced injury, including brain ischemia-induced cell death. 30876980 2019
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.010 GeneticVariation disease BEFREE Apolipoprotein E (APOE) genotype is a determinant of neurologic recovery after brain ischemia and traumatic brain injury. 25282659 2014
Entrez Id: 351
Gene Symbol: APP
APP 		0.020 AlteredExpression disease BEFREE The resulting brain ischemia dysregulates additionally expression of amyloid precursor protein and amyloid-processing enzyme genes that, in addition, ultimately compromise brain functions, leading over time to the complex alterations that characterize advanced sporadic Alzheimer's disease. 23519520 2013
Entrez Id: 351
Gene Symbol: APP
APP 		0.020 Biomarker disease BEFREE Because brain ischemia has recently been recognized to contribute to the pathogenesis of AD, we studied the effect of focal brain ischemia in 8- and 20-month-old mice overexpressing the 751-amino acid isoform of human APP. 11818564 2002
Entrez Id: 360
Gene Symbol: AQP3
AQP3 		0.200 Biomarker disease RGD Our findings indicated that dynamic changes of AQP3, -4, -5 and -8 expression could contribute to the development of cerebral edema after brain ischemia. 19616516 2009
Entrez Id: 361
Gene Symbol: AQP4
AQP4 		0.200 Biomarker disease RGD Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. 19616516 2009
Entrez Id: 362
Gene Symbol: AQP5
AQP5 		0.200 Biomarker disease RGD Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. 19616516 2009
Entrez Id: 343
Gene Symbol: AQP8
AQP8 		0.200 Biomarker disease RGD Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. 19616516 2009
Entrez Id: 41
Gene Symbol: ASIC1
ASIC1 		0.300 Biomarker disease CTD_human Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. 21307247 2011
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.010 GeneticVariation disease BEFREE The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. 24414230 2014
Entrez Id: 572
Gene Symbol: BAD
BAD 		0.200 Biomarker disease RGD Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3. 18078455 2008
Entrez Id: 572
Gene Symbol: BAD
BAD 		0.200 Biomarker disease RGD Cluster analysis of mRNA expression levels identifies multiple sequential patterns following focal cerebral ischemia. 22843461 2012
Entrez Id: 27113
Gene Symbol: BBC3
BBC3 		0.300 Biomarker disease CTD_human Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. 19095966 2009
Entrez Id: 596
Gene Symbol: BCL2
BCL2 		0.210 Therapeutic disease RGD Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxicity in the rat hippocampus. 15585409 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2 		0.210 Biomarker disease LHGDN This review focuses on the mechanisms by which Bcl-2 family members control the permeability of the mitochondrial membrane and influence other aspects of mitochondrial function after brain ischemia, concluding with discussion of the potential use of Bcl-2 for the treatment of cerebral ischemia. 15261486 2005
Entrez Id: 598
Gene Symbol: BCL2L1
BCL2L1 		0.200 Biomarker disease RGD Cluster analysis of mRNA expression levels identifies multiple sequential patterns following focal cerebral ischemia. 22843461 2012
Entrez Id: 598
Gene Symbol: BCL2L1
BCL2L1 		0.200 Biomarker disease RGD A high soy diet reduces programmed cell death and enhances bcl-xL expression in experimental stroke. 17706879 2007
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.330 Biomarker disease BEFREE Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. 28431607 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.330 GeneticVariation disease BEFREE Even though previous brain ischemia and WM lesion studies have been conducted and indicated that brain-derived neurotrophic factor (BDNF) might protect against neuronal cell death, the interaction between regional WMH volume and the BDNF Val66Met polymorphism on the cognitive performance of healthy elderly population remains unclear. 24275008 2014