Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 718
Gene Symbol: C3
C3 		0.500 Biomarker disease CTD_human Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice. 23199288 2013
Entrez Id: 842
Gene Symbol: CASP9
CASP9 		0.500 Biomarker disease RGD LLI may protect the brain by upregulating Akt, pAkt, pBAD, and Bcl-2 expression and downregulating caspase 9 and caspase 3 expression following transient cerebral ischemia. 21712070 2011
Entrez Id: 718
Gene Symbol: C3
C3 		0.500 Therapeutic disease RGD The protective effect of SCR(15-18) on cerebral ischemia-reperfusion injury. 22004711 2011
Entrez Id: 27429
Gene Symbol: HTRA2
HTRA2 		0.500 Therapeutic disease RGD UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in rats. 19462455 2009
Entrez Id: 27429
Gene Symbol: HTRA2
HTRA2 		0.500 Biomarker disease CTD_human Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1. 15306124 2004
Entrez Id: 842
Gene Symbol: CASP9
CASP9 		0.500 Biomarker disease RGD Activation of cell death pathway after a brief period of global ischemia in diabetic and non-diabetic animals. 15246841 2004
Entrez Id: 842
Gene Symbol: CASP9
CASP9 		0.500 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.310 Biomarker disease BEFREE In the present study, gerbils were orally pre‑treated with CIL, and changes of antioxidant enzymes including superoxide dismutase (SOD) 1 and SOD2, catalase (CAT) and glutathione peroxidase (GPX) in the hippocampal CA1 region following 5 min of transient cerebral ischemia were investigated and the neuroprotective effect of CIL in the ischemic CA1 region was examined. 28534982 2017
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.310 Biomarker disease BEFREE Here, we determined whether the antiapoptotic effects of sevoflurane postconditioning are associated with activation of the JAK2-STAT3 pathway after global transient cerebral ischemia in rats. 27337676 2017
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.310 Biomarker disease RGD SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. 23764464 2013
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.310 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
Entrez Id: 3717
Gene Symbol: JAK2
JAK2 		0.310 Biomarker disease HPO
Entrez Id: 57447
Gene Symbol: NDRG2
NDRG2 		0.300 Biomarker disease CTD_human NDRG2 is a novel p53-associated regulator of apoptosis in C6-originated astrocytes exposed to oxygen-glucose deprivation. 23451161 2013
Entrez Id: 134
Gene Symbol: ADORA1
ADORA1 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Therapeutic disease CTD_human Reduced oxidative stress promotes NF-kappaB-mediated neuroprotective gene expression after transient focal cerebral ischemia: lymphocytotrophic cytokines and antiapoptotic factors. 16868554 2007
Entrez Id: 4000
Gene Symbol: LMNA
LMNA 		0.300 Biomarker disease RGD Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. 17683050 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Therapeutic disease CTD_human Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats. 16538228 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Therapeutic disease CTD_human Oxidative stress transiently decreases the IKK complex (IKKalpha, beta, and gamma), an upstream component of NF-kappaB signaling, after transient focal cerebral ischemia in mice. 15829915 2005
Entrez Id: 94
Gene Symbol: ACVRL1
ACVRL1 		0.300 Biomarker disease RGD TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. 15781474 2005
Entrez Id: 3611
Gene Symbol: ILK
ILK 		0.300 Biomarker disease CTD_human Oxidative stress affects the integrin-linked kinase signaling pathway after transient focal cerebral ischemia. 15472100 2004
Entrez Id: 572
Gene Symbol: BAD
BAD 		0.300 Biomarker disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Therapeutic disease CTD_human Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. 12629175 2003
Entrez Id: 54205
Gene Symbol: CYCS
CYCS 		0.300 Biomarker disease CTD_human Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. 11333366 2001
Entrez Id: 94
Gene Symbol: ACVRL1
ACVRL1 		0.300 Biomarker disease HPO
Entrez Id: 4000
Gene Symbol: LMNA
LMNA 		0.300 Biomarker disease HPO