Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.080 | AlteredExpression | disease | BEFREE | RNA interference was used to downregulate Bmi-1 expression in a cervical cancer cell line (HeLa). | 21309753 | 2011 | ||||
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0.080 | AlteredExpression | disease | BEFREE | What's more, the levels of BMI-1 autoantibody increased significantly at stage I (0.672±0.019) compared to normal sera (P<0.001), and levels of BMI-1 autoantibodies were increased gradually during the tumor progression (stage I 0.672±0.019; stage II 0.775 ±0.019; stage III 0.890 ±0.027; stage IV 1.043±0.041), which were significantly correlated with disease progression of cervical cancer (P<0.001). | 22132147 | 2011 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We investigated whether BMI-1 is a marker for cervical cancer by detecting the expression of BMI-1 in cervical cancer. | 22898137 | 2012 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Finally, tissue array studies demonstrated that expression of Bmi1 increased with the severity of cervical dysplasia, suggesting a potential role in the progression of cervical cancer. | 23592995 | 2013 | ||||
|
0.080 | Biomarker | disease | BEFREE | The newly identified miR-376c/BMI1 pathway provides an insight into cervical cancer progression and may represent a novel therapeutic target. | 27345009 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | These results suggest overexpression of miR-132 enhances the radiosensitivity of CC cells by down-regulating Bmi-1 and that miR-132 may be a useful new target for the treatment of CC. | 29113342 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Aberrantly elevated Bmi1 promotes cervical cancer tumorigenicity and tumor sphere formation via enhanced transcriptional regulation of Sox2 genes. | 31173263 | 2019 | ||||
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0.080 | Biomarker | disease | BEFREE | Our study demonstrates that downregulation of hsa_circ_0007534 represses the proliferation and invasion of cervical cancer through regulating the miR-498/BMI-1 axis, suggesting the hsa_circ_0007534/miR-498/BMI-1 axis as a potential therapeutic target to treat cervical cancer. | 31445025 | 2019 |