Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE Furthermore, TUNEL+ cells and the relative caspase-3 activity in the CC cells were increased in the RT/BE group compared to those in the RT alone group. 28963664 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Moreover, knockdown of <i>Lnc-IL7R</i> by two different siRNAs in cervical cancer cell lines Hela and SiHa induced impaired cell vitality and caspase-3-dependent apoptosis <i>in vitro</i> Furthermore, inhibition of <i>Lnc-IL7R in vivo</i> significantly restricted the tumor growth with decreased expressions of proliferation index Ki-67 and <i>Lnc-IL7R</i> These data indicated that <i>Lnc-IL7R</i> predicts a poor clinical outcome of cervical cancer patients, and knockdown of <i>Lnc-IL7R</i> is amenable to the treatment of cervical cancer. 29720427 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE Clonogenic assay, PCNA staining, TUNEL staining and caspase-3 activity assay were used to investigate the direct in vitro effect of T. Vag on human cervical cancer by using HeLa cells. 30194152 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 GeneticVariation disease BEFREE These data indicate that through upregulating the expression of caspase-3, the TT genotype of caspase-3 rs1049216 can be associated with not only the risk of cervical cancer but also the progression of this cancer. 28114230 2017
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Moreover, α-mangostin also repressed tumor growth in accordance with increased levels of p-ASK1, p-p38, cleaved-PARP and cleaved-caspase-3 in the tumor mass from the mouse xenograft model of cervical cancer. 28537893 2017
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE CONCLUSIONS Our results suggest that overexpression of miR-148b protects against cervical cancer by inducing G1/S-phase cell cycle arrest and apoptosis through caspase-3-dependent manner, and overexpression of miR-148b might develop a therapeutic intervention for cervical cancer. 27505047 2016
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE Up-regulation of ENST00000420168, ENST00000564977 and down-regulation of TCONS_00010232 might stimulate FOXQ1 expression and suppress CASP3 expression in HPV-18 positive cervical cancer cell, which lead to HPV-induced proliferation and deficiency in apoptosis. 27363024 2016
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Significant improvement of XIAP gene silencing and cleaved caspase-3 activation was achieved, resulting in good therapeutic effect on human cervical cancer xenograft model in nude mice. 26733262 2016
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Therefore, our research revealed the mechanistic links between miR-744 and Bcl-2 in the pathogenesis of cervical cancer through modulation of Caspase-3, leading to the inhibition of cervical cancer cell growth. 27261616 2016
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE Our data demonstrated that MALAT1 was involved in cervical cancer cell growth, cell cycle progression, and invasion through the regulation of gene expression, such as caspase-3, -8, Bax, Bcl-2, and BclxL, suggesting that MALAT1 could have important implications in cervical cancer biology. 20213048 2010
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE Stable transfer of the extrinsic Smac gene and its over-expression in cervical cancer cell line could significantly enhance the expression and activities of cellular caspase-3 and ameliorate apoptosis-inducing effects of irradiation on cancer cells, which was a novel strategy to improve radiotherapeutic effects on cervical cancer. 15740652 2005