Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.500 Biomarker disease CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087 2018
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.500 Biomarker disease RGD Ammonia reduction with ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct-ligated cirrhotic rats. 21903766 2012
Entrez Id: 79258
Gene Symbol: MMEL1
MMEL1 		0.500 Biomarker disease CTD_human Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. 20639879 2010
Entrez Id: 79258
Gene Symbol: MMEL1
MMEL1 		0.500 SusceptibilityMutation disease ORPHANET
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 GeneticVariation disease GWASCAT POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33. 30643196 2019
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 Biomarker disease BEFREE Furthermore, significantly increased TL1A had been detected in liver tissues and mononuclear cells of patients with primary biliary cirrhosis (PBC). 30906791 2019
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 GeneticVariation disease BEFREE Along with corroborating known PBC-associated loci (TNFSF15, HLA-DRA), risk haplotypes may potentially model cis-interactions that regulate gene expression. 29773854 2018
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 GeneticVariation disease GWASCAT Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. 28062665 2017
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 GeneticVariation disease BEFREE A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) and POU2AF1 (rs4938534) as strong susceptibility loci for PBC. 28062665 2017
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 AlteredExpression disease BEFREE In summary, we provide evidence that variance within TNFSF15 has the potential to affect cytokine expression across a range of tissues and thereby contribute to protection from infectious diseases such as leprosy, while increasing the risk of immune-mediated diseases including CD and PBC. 27507062 2016
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 Biomarker disease BEFREE TNFSF15 and ICOSLG-CXCR5 might constitute a shared pathogenic pathway in the development of PBC and CD in the Japanese population, whereas IL12B-STAT4-NFKB1 might constitute an opposite pathogenic pathway, reflecting the different balance between Th1 and Th17 in the two diseases. 26084578 2015
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 GeneticVariation disease BEFREE This study identified the causal variant for PBC susceptibility in the TNFSF15 locus and clarified its underlying molecular mechanism. 25899471 2015
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 Biomarker disease BEFREE This suggests that modulation of TL1A-DR3 interaction may be a potential therapeutic target in several autoimmune diseases, including IBD, RA, AS, and PBC. 24453414 2013
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 SusceptibilityMutation disease ORPHANET Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. 23000144 2012
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 GeneticVariation disease GWASDB Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. 23000144 2012
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 GeneticVariation disease GWASCAT Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. 23000144 2012
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15 		0.480 GeneticVariation disease BEFREE Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. 23000144 2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4 		0.470 Biomarker disease BEFREE Immunogenetic studies have identified polymorphisms of the IL-12/STAT4 pathway as being associated with PBC. 31803181 2019
Entrez Id: 6775
Gene Symbol: STAT4
STAT4 		0.470 PosttranslationalModification disease BEFREE This effect was mediated by the rapid and strong phosphorylation of STAT4 on Treg cells from patients with PBC and pSS (p < 0.05) but not PSC and HC. 30119881 2018
Entrez Id: 6775
Gene Symbol: STAT4
STAT4 		0.470 GeneticVariation disease GWASCAT A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. 28425483 2017
Entrez Id: 6775
Gene Symbol: STAT4
STAT4 		0.470 Biomarker disease BEFREE Potential functional implications of key findings are discussed including the IL-12/STAT4 pathway in PBC and the CD28/IL-2 pathway in PSC. 26347073 2016
Entrez Id: 6775
Gene Symbol: STAT4
STAT4 		0.470 GeneticVariation disease BEFREE The effect of ICOSLG and CXCR5 variants were concordant but the effect of STAT4, NFKB1 and IL12B variants were discordant for PBC and CD. 26084578 2015
Entrez Id: 6775
Gene Symbol: STAT4
STAT4 		0.470 GeneticVariation disease BEFREE STAT4 gene polymorphism has been shown to be associated with the antiviral response in chronic hepatitis C and drug-induced liver injury (DILI), primary biliary cirrhosis (PBC), HCV-associated liver fibrosis and in hepatocellular carcinoma (HCC). 25798064 2015
Entrez Id: 6775
Gene Symbol: STAT4
STAT4 		0.470 Biomarker disease BEFREE Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population. 24648611 2014
Entrez Id: 6775
Gene Symbol: STAT4
STAT4 		0.470 GeneticVariation disease GWASCAT Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. 23000144 2012