|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the DRB1*11 allele in the PBC group was about half of that seen in the Sardinian HCs (7.5% vs 15.7%) (<i>p</i> = ns).
|
28588884 |
2017 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together with DRB1*1101, DRB1*0801 has been associated with several diseases including multiple sclerosis and primary biliary cirrhosis, which themselves are associated with cognitive impairment.
|
26473500 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the DQB1*03:01 allele (21.4% vs. 39.2%, Pc < 0.0001, OR = 0.42) and DRB1*12:02-DQB1*03:01 haplotype (6.9% vs. 14.6%, P = 0.015, OR = 0.43) were significantly decreased in PBC patients compared with controls.
|
23809616 |
2014 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1*08:01 (DR0801) and DRB1*11:01 (DR1101) are highly homologous alleles that have opposing effects on susceptibility to primary biliary cirrhosis (PBC).
|
23543758 |
2013 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis.
|
22573116 |
2012 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were found with PBC susceptibility for the DRB1*08:03-DQB1*06:01 (13% versus 6%; P = 0.000025; odds ratio [OR] = 2.22) and DRB1*04:05-DQB1*04:01 haplotypes (17% versus 13%; P = 0.044; OR = 1.38).
|
21953406 |
2012 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The picture has become more complete when strong protective associations between PBC and the HLA DRB1*11 and DRB1*13 alleles were found in Italian and UK series.
|
21563204 |
2011 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We determined whether TNF-alpha promoter polymorphisms (G-308A and G-238A) and alleles of HLA class II (HLA-DRB1) might be associated either with PBC occurrence and severity in Italian populations from two distinct areas.
|
19758199 |
2009 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The disease is more prevalent in families with PBC and candidate gene case-control studies have linked PBC with DRB1(*)08 human leucocyte antigen class II alleles.
|
19018986 |
2009 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, human leukocyte antigen genotyping detected the alleles DQB1*0601 and DRB1*0803, which are related to both PBC and ITP in Japanese patients.
|
18416479 |
2008 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
After correction for multiple testing, DRB1*08 [odds ratio (OR), 3.3; 95% confidence interval (CI), 2.4-4.5] and DRB1*02 (OR 0.9; 95% CI 0.8-1.2) were significantly associated with PBC, whereas alleles DRB1*11 (OR 0.4; 95% CI 0.3-0.4) and DRB1*13 (OR 0.7; 95% CI 0.6-0.9) were protective.
|
19003916 |
2008 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the inability to replicate reported associations has been a recurring problem, with the only consistently reported genetic association that between PBC and HLA-DRB1*0801.
|
16941709 |
2006 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The susceptibility to PBC in Chinese individuals is associated with DRB1*0701 allele.
|
16481299 |
2006 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the DRB1*08-DQA1*0401-DQB1*04 haplotype was significantly associated with PBC, consistent with other studies, this haplotype nevertheless represented only 19% (14/72) of all PBC patients and can account for only a minority of the risk of PBC.
|
15713222 |
2005 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the presence of the HLA-DRB1*08 antigen has been reported in less than one-third of PBC patients from Northern Europe and Japan.
|
12911663 |
2003 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that DRB1*0803 is one of the HLA class II genes related to an increased risk of primary biliary cirrhosis in Japanese individuals.
|
7699227 |
1994 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The major histocompatibility complex (MHC) class-II alleles at the DRB1, DQB1 and DPB1 loci were investigated in 40 patients with primary biliary cirrhosis (PBC) and 43 local healthy controls.
|
7904771 |
1994 |