×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
Biomarker
disease
BEFREE
Immunogenetic studies have identified polymorphisms of the IL-12/STAT4 pathway as being associated with PBC .
31803181
2019
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
PosttranslationalModification
disease
BEFREE
This effect was mediated by the rapid and strong phosphorylation of STAT4 on Treg cells from patients with PBC and pSS (p < 0.05) but not PSC and HC.
30119881
2018
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
GeneticVariation
disease
GWASCAT
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis.
28425483
2017
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
Biomarker
disease
BEFREE
Potential functional implications of key findings are discussed including the IL-12/STAT4 pathway in PBC and the CD28/IL-2 pathway in PSC.
26347073
2016
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
GeneticVariation
disease
BEFREE
The effect of ICOSLG and CXCR5 variants were concordant but the effect of STAT4 , NFKB1 and IL12B variants were discordant for PBC and CD.
26084578
2015
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
GeneticVariation
disease
BEFREE
STAT4 gene polymorphism has been shown to be associated with the antiviral response in chronic hepatitis C and drug-induced liver injury (DILI), primary biliary cirrhosis (PBC ), HCV-associated liver fibrosis and in hepatocellular carcinoma (HCC).
25798064
2015
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
Biomarker
disease
BEFREE
Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population.
24648611
2014
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
GeneticVariation
disease
GWASCAT
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
23000144
2012
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
GeneticVariation
disease
GWASDB
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
22961000
2012
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
GeneticVariation
disease
GWASDB
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
23000144
2012
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
GeneticVariation
disease
GWASDB
Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.
22936693
2012
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
GeneticVariation
disease
BEFREE
Among 21 non-HLA susceptibility loci for PBC identified in GWASs of individuals of European descent, three loci (IL7R, IKZF3, and CD80) showed significant associations (combined p = 3.66 × 10(-8), 3.66 × 10(-9), and 3.04 × 10(-9), respectively) and STAT4 and NFKB1 loci showed suggestive association with PBC (combined p = 1.11 × 10(-6) and 1.42 × 10(-7), respectively) in the Japanese population.
23000144
2012
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
GeneticVariation
disease
GWASCAT
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
22961000
2012
×
Entrez Id:
6775
Gene Symbol:
STAT4
STAT4
0.470
Biomarker
disease
CTD_human
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
21399635
2011