Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 53347
Gene Symbol: UBASH3A
UBASH3A
0.400 Biomarker disease CTD_human Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. 27992413 2017
Entrez Id: 4485
Gene Symbol: MST1
MST1
0.400 GeneticVariation disease GWASCAT Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. 27992413 2017
Entrez Id: 53347
Gene Symbol: UBASH3A
UBASH3A
0.400 GeneticVariation disease GWASCAT Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. 27992413 2017
Entrez Id: 53347
Gene Symbol: UBASH3A
UBASH3A
0.400 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.400 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 4485
Gene Symbol: MST1
MST1
0.400 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 4485
Gene Symbol: MST1
MST1
0.400 GeneticVariation disease GWASCAT Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. 23603763 2013
Entrez Id: 4485
Gene Symbol: MST1
MST1
0.400 Biomarker disease CTD_human Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. 21151127 2011
Entrez Id: 4485
Gene Symbol: MST1
MST1
0.400 GeneticVariation disease GWASCAT Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. 21151127 2011
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.400 Biomarker disease CTD_human Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. 12612912 2003
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
0.320 GeneticVariation disease BEFREE To generalize these observations, we suppressed β-catenin in Mdr2 knockout (KO) mice, which develop sclerosing cholangitis due to regurgitation of BA from leaky ducts. 31489648 2019
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
0.320 Biomarker disease CTD_human Galunisertib modifies the liver fibrotic composition in the Abcb4Ko mouse model. 29808285 2018
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
0.320 Biomarker disease BEFREE Because MDR2 (rodent orthologue of human MDR3) knockout mice develop sclerosing cholangitis, it is attractive to speculate that MDR3 defects could also play an important role in cholangiopathies in humans. 17295178 2007
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
0.320 Biomarker disease CTD_human Multidrug resistance gene 2 knockout mice (Mdr2(-/-)) represent a well-characterized model for sclerosing cholangitis. 16472600 2006
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.300 Biomarker disease CTD_human Consistent with a role for HIFs in liver fibrosis in cholestatic liver disease, nuclear HIF-1α protein was present in macrophages, hepatocytes, and fibroblasts in the livers from patients with primary biliary cirrhosis and primary sclerosing cholangitis. 22271822 2012
Entrez Id: 10018
Gene Symbol: BCL2L11
BCL2L11
0.300 Biomarker disease CTD_human Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. 21151127 2011
Entrez Id: 8209
Gene Symbol: GATD3A
GATD3A
0.110 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 8209
Gene Symbol: GATD3A
GATD3A
0.110 Biomarker disease BEFREE PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: possible implications for sclerosing cholangitis. 23207146 2013
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.100 GeneticVariation disease GWASCAT Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. 28779025 2018
Entrez Id: 30820
Gene Symbol: KCNIP1
KCNIP1
0.100 GeneticVariation disease GWASCAT Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. 28779025 2018
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease GWASCAT Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. 28779025 2018
Entrez Id: 107986041
Gene Symbol: LINC01967
LINC01967
0.100 GeneticVariation disease GWASCAT Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. 28779025 2018
Entrez Id: 51164
Gene Symbol: DCTN4
DCTN4
0.100 GeneticVariation disease GWASCAT Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. 28779025 2018
Entrez Id: 11262
Gene Symbol: SP140
SP140
0.100 GeneticVariation disease GWASCAT Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. 28779025 2018
Entrez Id: 6311
Gene Symbol: ATXN2
ATXN2
0.100 GeneticVariation disease GWASCAT Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. 27992413 2017