Then, we determined the impact of the wholesale inactivation of the genes encoding IL-1R1 (Il1r1<sup>-/-</sup>), NLRP3 (Nlrp3<sup>-/-</sup>) or caspase-1 (Casp1<sup>-/-</sup>) on epithelial injury and bile duct obstruction.
The results indicated that PLP could ameliorate ANIT-induced cholestasis in rats and the anti-inflammatory effect of PLP might be related to regulating NF-κB-NLRP3 inflammasome pathway.
(2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.