Gene: PTEN ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.030 Biomarker disease BEFREE PTEN disruption statistically correlated with increased Ki-67 proliferation index, an established marker of poor outcome for chordoma. 26247786 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.030 GeneticVariation disease BEFREE When this data is paired with the studies showing 18 of 21 chordoma samples displaying copy loss at the locus for CDKN2A, 17 of 21 chordoma samples displaying copy loss at PTEN, and 3 of 4 chordoma samples displaying deletion at the SMARCB1 locus, we can infer that a loss of heterozygosity at these three loci may play a significant role in chordoma pathogenesis. 24983247 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.030 AlteredExpression disease BEFREE PTEN expression was absent by immunohistochemistry in 19 of 147 (13%) analysed chordomas, only one of which revealed high-level polysomy of EGFR. 21171079 2011