Source: BEFREE ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE The prevalences of HA and HB fall within the ranges reported in more developed countries; the consumption of FVIII and FIX was in line with that of other European countries (France, United Kingdom) and Canada. 30865582 2020
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE <b>Objective:</b> An extended half-life factor IX (FIX) fusion protein linking recombinant FIX with recombinant human albumin (rIX-FP), indicated for the treatment of hemophilia B, was approved by the European Medicines Agency in May 2016. 31469321 2020
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 AlteredExpression disease BEFREE The accuracy of the one-stage clotting assay to measure recombinant FIX Fc fusion protein (rFIXFc) activity was evaluated by major Japanese hemophilia treatment centers and commercial laboratories that measure factor IX activity for a majority of hemophilia B patients in Japan. 31820573 2020
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE Phenotypic characterization of haemophilia B - Understanding the underlying biology of coagulation factor IX. 31180618 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 AlteredExpression disease BEFREE Etranacogene dezaparvovec (AMT-061 phase 2b): normal/near normal FIX activity and bleed cessation in hemophilia B. 31698454 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE Immune responses following gene transfer of coagulation factor IX (FIX) for the treatment of the bleeding disorder hemophilia B has been extensively investigated in multiple animal models. 28645365 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 AlteredExpression disease BEFREE Factor IX:C (FIX:C) levels vary in hemophilia B carriers even in pedigrees with a unifying genetic defect. 31446339 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE In bleeding CRM<sup>-</sup> hemophilia B mice, the times to first clot at a saphenous vein injury site after the infusions of the FIX agents are significantly different, at FIX<sub>WT</sub> < FIX<sub>FC</sub> < FIX<sub>Alb</sub> Dysfunctional forms of FIX, however, circulate in the majority of patients with hemophilia B (CRM<sup>+</sup>). 30992271 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE Postmarketing safety and effectiveness of recombinant factor IX (nonacog alfa) in Japanese patients with haemophilia B. 31168882 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 AlteredExpression disease BEFREE Adeno-associated viral vectors (AAV) mediating expression of hFIX-Alb and hFIX-Fc fusion proteins was investigated for gene therapy of HB to explore if their extended half-life translates to higher plasma levels of FIX. 30520547 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE Haemophilia is a serious inherited bleeding disorder resulting from a deficiency of coagulation factor VIII (haemophilia A) or coagulation factor IX (haemophilia B). 31069799 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 GeneticVariation disease BEFREE We have reported the efficacy and safety of AMT-060, an investigational gene therapy comprising an adeno-associated virus serotype 5 capsid encapsidating the codon-optimized wild-type human factor IX (WT h<i>FIX</i>) gene with a liver-specific promoter, in patients with severe hemophilia B. 31709273 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE Hemophilia B is an X linked recessive deficiency of factor IX that presents with a range of clinical severity that co-relates with factor levels. 30795708 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE Systematic review and analysis of efficacy of recombinant factor IX products for prophylactic treatment of hemophilia B in comparison with rIX-FP. 31094591 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE The developed clonal producer cell line and the purification process employed in this work allow for economically sound industrial-scale production of biosimilar factor IX for hemophilia B therapy. 29713519 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 GeneticVariation disease BEFREE A new in silico approach to investigate molecular aspects of factor IX missense causative mutations and their impact on the hemophilia B severity. 30817849 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 GeneticVariation disease BEFREE This mechanism helps mitigate safety concerns of unregulated coagulation and supports the expanded use of FIX-R338L in HB therapy. 31219805 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 GeneticVariation disease BEFREE Recombinant Adeno-Associated Viral Vectors Expressing Human Coagulation FIX-E456H Variant in Hemophilia B Mice. 31659733 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE Prednisolone treatment induced temporary factor IX normalization in mild hemophilia B who required an epidural infiltration: A case report. 31272859 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 GeneticVariation disease BEFREE Hemophilia A (HA) and hemophilia B (HB) are X-linked bleeding disorders due to inheritable deficiencies in either coagulation factor VIII (FVIII) or factor IX (FIX), respectively. 30705923 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 Biomarker disease BEFREE Hemophilia is an X-linked congenital bleeding disorder caused by a deficiency of coagulation factor VIII (FVIII) in hemophilia A or factor IX (FIX) in hemophilia B. 31427262 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 AlteredExpression disease BEFREE In 2011, the St. Jude/UCL phase 1/2 trial was the first to provide clear evidence of a stable dose-dependent increase in FIX levels in patients with severe hemophilia B following a single administration of adeno-associated viral (AAV) vectors. 31808868 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 AlteredExpression disease BEFREE We determined as a proof-of-principle that adenoviral delivery of CRISPR/Cas9 is capable of corrective gene addition, leading to long-term augmentation of FIX activity and phenotypic correction in a murine model of juvenile HB. 30771412 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 GeneticVariation disease BEFREE Missense mutations in the first five exons of F9, which encodes factor FIX, represent 40% of all mutations that cause hemophilia B. 31253089 2019
Entrez Id: 2158
Gene Symbol: F9
F9
1.000 AlteredExpression disease BEFREE The activity of factor IX was <50% and the inhibitor was increased, which confirms the diagnosis of hemophilia B. 31106079 2019