| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | group | BEFREE | In this study, we investigated the role of sirtuin 1 (SIRT1) in neuroinflammatory priming and cognitive deficits in aged rats after anesthesia and surgery. | 30972182 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | However, depressive-like behaviors and cognitive deficits were observed again in rats subjected to stereotaxic injection with EX527 or sh-SIRT1. | 30716615 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | Here, we investigated the role of sirtuin 1 (SIRT1) and salidroside in CNS inflammation-induced cognitive deficits model. | 30848530 | 2019 | ||||
|
0.080 | PosttranslationalModification | group | BEFREE | Our findings indicated that Schisanhenol can attenuate scopolamine-induced learning impairment and enhance cognitive function, the mechanism via improve the cholinergic system and antioxidant ability, activate SIRT1-PGC1α signaling, inhibit the phosphorylation of Tau, and would be an effective candidate against cognitive disorders, such as Alzheimer's disease. | 30033800 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus. | 30414004 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke. | 30196826 | 2018 | ||||
|
0.080 | Biomarker | group | BEFREE | Our results suggest that HBO-PC can protect the brain from injury caused by ischemia-reperfusion and that Sirt1 is a potential molecular target for therapeutic approaches designed to minimize cognitive deficits caused by cerebral ischemia. | 28937253 | 2017 | ||||
|
0.080 | Biomarker | group | BEFREE | Chikusetsu saponin IVa attenuates isoflurane-induced neurotoxicity and cognitive deficits via SIRT1/ERK1/2 in developmental rats. | 28979702 | 2017 |