Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice. 31839610 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology. 31783135 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Our results showed that tan IIA significantly ameliorates cognitive deficits and improves spatial learning ability of APP/PS1 mice in the nest-building test, novel object recognition test and Morris water maze test. 31778727 2020
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation group BEFREE Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: rs75548401" genes_norm="2629">p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients. 31505070 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Fructooligosaccharides Ameliorating Cognitive Deficits and Neurodegeneration in APP/PS1 Transgenic Mice through Modulating Gut Microbiota. 30816709 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Long-term icariin treatment ameliorates cognitive deficits via CD4<sup>+</sup> T cell-mediated immuno-inflammatory responses in APP/PS1 mice. 31190768 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation group BEFREE Sleep state-specific (REM, NREM) OSA may be differentially associated with varying dimensions of cognitive deficits in middle-aged to older adults, and such associations are likely to be modified by genetic factors, include APOE polymorphisms. 31383233 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide. 31847879 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE No significant difference was found between the APP/PS2 and wild-type mice at 2-6 months of age in terms of novel object recognition memory; subsequently, however, APP/PS2 mice showed a clear cognitive deficit at 12 months of age. 30047036 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice. 30504006 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice. 31467256 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Our results indicate that NTP reduces neuroinflammation and improves the cognitive deficits in APP/PS1 mice possibly via BDNF/NF-κB pathway. 30972181 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 AlteredExpression group BEFREE NC009-1 further rescued the downregulated APOE and TRKA and reduced Aβ and tau levels in hippocampus and cortex, and ameliorated cognitive deficits in streptozocin-induced hyperglycemic 3×Tg-AD mice. 30689566 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker group BEFREE We used logistic regression analysis in the combined sample across the three centers to investigate center effects with regard to likelihood of biomarker abnormality while taking potential common predictors (e.g., age, sex, apolipoprotein E (APOE) status, subtle cognitive deficits, depressive symptoms) into account. 30654834 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 AlteredExpression group BEFREE A Morris water maze test was performed and showed that overexpression of miR-361-3p improved cognitive deficits in APP/PS1 mice. 31601077 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau proteins, which are believed to lead to neural damage that translates into brain dysfunction and cognitive deficits. 30599271 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE For the accumulation of intracellular hyperphosphorylated tau proteins is a major pathogenic factor in neurodegeneration of AD, the distributional pattern of tau could highlight the affected brain regions associated with specific cognitive deficits. 31724513 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation group BEFREE We used magnetic resonance imaging, APOE genotyping and neurocognitive assessments to examine young adults (mean age: 29.1 ± 6.3 years) with major depressive disorder and a current depressive episode, presenting with or without cognitive deficits. 30388556 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation group BEFREE Our data also indicate that introduction of the Swedish mutation alone in endogenous APP is not sufficient to produce either AD-related brain pathology or cognitive deficits in mice. 30894120 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 AlteredExpression group BEFREE At 9 months of age, untreated 3×Tg-AD mice vs. wild-type (WT) controls displayed cognitive deficits in behavioral assays and, at 12 months, elevated levels of hippocampal amyloid beta-protein (Aβ), amyloid precursor protein (APP), tau phosphorylation, and pro-inflammatory cytokines. 31603034 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE As a result, the nanochaperone reduces Aβ burden, attenuates Aβ-induced inflammation, and eventually rescues the cognitive deficits of APP/PS1 transgenic AD mice. 31763156 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Taken together, our findings show that the TIPE2 expression level was negatively correlated with the pathogenesis of Alzheimer's disease, and overexpression of TIPE2 attenuates cognitive deficits in APP/PS1 mice, suggesting TIPE2 is a potential target for pharmacological intervention and improvement of cognitive deficits.Graphical Abstract . 31286344 2019
Entrez Id: 2332
Gene Symbol: FMR1
FMR1
0.400 Biomarker group BEFREE Loss of the fragile X mental retardation protein, FMRP, engenders molecular, behavioral, and cognitive deficits in FXS patients. 30365357 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss. 31685977 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE In behavioral studies, SAR502250 improved the cognitive deficit in aged transgenic APP(SW)/Tau(VLW) mice or in adult mice after infusion of Aβ<sub>25-35</sub>. 31792284 2019