Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE All-trans retinoic acid cotreatment (1 mg/kg BW, i.p. daily) of DSS-treated mice (3% in drinking water for 7 days) alleviated colitis-associated weight loss, diarrheal phenotype, and induction of IL-1β and CXCL1 and a decrease in DRA mRNA and protein levels in the colon. 31634391 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE A dozen were shown to possess improved properties, among which inhibition of YO-PRO-1/TO-PRO-3 uptake and IL1β release upon BzATP activation of the receptor and dampening signs of DSS-induced colitis on mice, in comparison with reference antagonist GSK1370319A. 31525963 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE In this study, extracellular vesicles (EVs) from cultured medium of bone-marrow mesenchymal stem cells (BMSCs) transfected with recombinant lentiviruses can serve as a stable delivery system and overexpress miR-146a, which significantly inhibited TNF receptor-associated factor 6 (TRAF6) and IL-1 receptor-associated kinase 1 (IRAK1) expression in TNBS-induced colitis of rats. 30654310 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Here, we show that ISR activation by arsenite (Ar) results in suppression of IL-1β production in macrophages and inhibition of DSS-induced colitis in a murine model through a novel posttranscriptional and translation regulatory (PTR) mechanism. 30578631 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE DAI evaluation, colon length, colon tissue morphology, histologic damage scores and relative protein concentrations (MPO, TNF-α and IL-1β) demonstrated that the Alg/Chi/IL-1Ra microcapsules alleviated DSS-induced colitis in mice. 30779979 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE We found that the incubation of MSCs with TNF-α and IFN-γ aggravates colitis, where high levels of pro-inflammatory factors, such as interleukin (IL)-17, IL-8, IL-12, IL-1β, transforming growth factor (TGF)-β, TNF-α and IFN-γ, were secreted. 31632588 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Intravenously administered MSCs exhibited modest anti-inflammatory capacity in the acute phase of colitis by reducing IL-1β protein levels in the inflamed colon. 30611671 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE We studied the effect of heat-killed cells of <i>E. faecalis</i> on NLRP3 inflammasome activation in THP-1-derived macrophages.Pretreatment of <i>E. faecalis</i> or NLRP3 siRNA can inhibit NLRP3 inflammasome activation in macrophages in response to fecal content or commensal microbes, <i>P. mirabilis</i> or <i>E. coli</i>, according to the reduction of caspase-1 activation and IL-1β maturation.Mechanistically, <i>E. faecalis</i> attenuates the phagocytosis that is required for the full activation of the NLRP3 inflammasome.In in vivo mouse experiments, <i>E. faecalis</i> can ameliorate the severity of intestinal inflammation and thereby protect mice from dextran sodium sulfate (DSS)-induced colitis and the formation of CRC in wild type mice.On the other hand, <i>E. faecalis</i> cannot prevent DSS-induced colitis in NLRP3 knockout mice. 30823406 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE NLRP3 inflammasome has been reported to be associated with inflammatory bowel disease including colitis due to its potential ability to induce IL-1β secretion. 30901677 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE PAP-1 also reduced the expression of Kv1.3, iNOS, NLRP3, caspase-1p20 and IL-1β on macrophages in colitis mice. 31351364 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Exaggerated NLRP3 and IL-1β expression in <i>Vsig4<sup>-/-</sup></i> mice is accountable for deleterious disease severity in experimental autoimmune encephalomyelitis (EAE) and resistance to dextran sulfate sodium (DSS)-induced colitis. 30662948 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 GeneticVariation disease BEFREE In addition, key cytokines associated with colitis (IL-1β, IL-6, and IL-17A) were significantly suppressed, following treatment with M2b macrophage exosomes. 31749791 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE This compound also decreases the levels of TNF-α, IL-6, and IL-1β in intestinal tissue of mice with experimental colitis in a concentration-dependent manner. 30548286 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE The treatment with LPPp reduced the levels of cytokine IL-1β, contributing to the reduction of colon inflammation. 31175857 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Furthermore, ZFE effectively modulated the mRNA expression of redox-sensitive transcription factors, such as nuclear factor (erythroid-derived 2)-like 2 and heme oxygenase-1, downregulated the expression of p38 mitogen-activated protein kinase, and upregulated that of vascular endothelial growth factor A and interleukin-1β in AcOH-induced colitis in rats. 29518435 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Seventy-two hours following colitis induction, macroscopic and microscopic mucosal lesions, and the colonic levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β) were determined. 30318564 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Intraperitoneally administered MSCs (2 × 10<sup>6</sup>) significantly reduced progression of DSS-induced colitis and reduced serum levels of inflammatory cytokines (IL-1β, IL-12, and IL-6). 29471245 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE In consistence with these results, COMMD10-deficiency in Ly6C<sup>hi</sup> monocytes, but not in intestinal-resident lamina propria macrophages, led to increased IL-1β production and aggravated colonic inflammation in a model of DSS-induced colitis. 30487795 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE This study was performed in rats with dinitrobenzenesulfonic acid (DNBS)-induced colitis, to investigate how the direct blockade of NLRP3 inflammasome with an irreversible inhibitor (INF39) compares with Ac-YVAD-cmk (YVAD, caspase-1 inhibitor) and anakinra (IL-1β receptor antagonist), acting downstream on NLRP3 signaling. 30559669 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1β production. 30396035 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Thus, we have identified a dual role for myeloid PTPN2 in directly regulating inflammasome activation and IL-1β production to suppress pro-inflammatory responses during colitis but promote intestinal tumor development. 29444435 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE <b>Materials and Methods:</b> Healthy human colonic mucosal strips (4 × 10 mm) were incubated in carbogenated culture medium at 37°C for 16 h. Proinflammatory cytokines TNFα and IL-1β (each 10 ng/mL) were used to induce colitis in mucosal strips, and the effects of Panx1 and P2X7R on cytokines-induced tissue damage were determined in the presence of the Panx1 channel blocker <sup>10</sup>Panx1 (100 μM) and P2X7R antagonist A438079 (100 μM). 30127744 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE The results indicated that single knockout (KO) mice of IL-1β or IL-18, and double KO mice of both IL-1β and IL-18 were hyporesponsive to DNBS-induced colitis compared to wild type (WT) mice, in which double KO were less sensitive than single KO mice. 29963998 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1β) and tumor necrosis factor alpha (Tnf-α) genes. 30415241 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE The synthesis of LL-37 was enhanced with butyrate (a product of bacterial fermentation) and interleukin-1β (IL-1β) (a proinflammatory cytokine in colitis) in the presence of exogenously added purified MUC2. 28069814 2017