Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE In this study, we evaluated the effect of IL-17A on colitis in IL-10-deficient (Il10-/-) mice. 31755523 2020
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE VPR-254 reduced the production of key pro-inflammatory cytokines (e.g., IL-17) in ex vivo and in vivo models of colitis. 31549280 2020
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE Contrastingly, enterotoxigenic Bacteroides fragilis (ETBF) is highly associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC), rapidly inducing IL-17-dependent murine colitis and tumorigenesis. 30279518 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE Importantly, intestinal NIK signaling is active in mouse models of colitis and patients with inflammatory bowel diseases; meanwhile, constitutive NIK signaling increases the susceptibility to inflammatory injury by inducing ectopic M-cell differentiation and a chronic increase of IL-17A. 30737385 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE Importantly, injection of anti-IL-17 intraperitoneally partially protected P2ry6<sup>-</sup><sup>/</sup><sup>-</sup> mice from DSS-induced colitis. 31271845 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 AlteredExpression disease BEFREE Notably, lentivirus-mediated overexpression of Ascl2 remarkably alleviated the severity of 2,4,6-trinitrobenzenesulfonic acid solution (TNBS)-induced colitis in mice, with decreased level of colonic IL-17A. 30722992 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 GeneticVariation disease BEFREE In addition, key cytokines associated with colitis (IL-1β, IL-6, and IL-17A) were significantly suppressed, following treatment with M2b macrophage exosomes. 31749791 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 AlteredExpression disease BEFREE RhoA<sup>ΔCD4</sup> mice had a similar phenotype to Pggt1b<sup>ΔCD4</sup> mice, including development of colitis, increased numbers of CD4+ T cells in colon, increased expression of integrin alpha4beta7 by CD4+ T cells, and increased levels of IL17A and other inflammatory cytokines in lamina propria. 31302143 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE In a 2,4,6-trinitrobenzenesulfonic acid-induced colitis model, mice carrying VDR deletion in gut epithelial cells [VDRflox/flox (VDRf/f);Villin-Cre or VDRΔIEC] or in colonic epithelial cells (VDRf/f;CDX2-Cre or VDRΔCEC) developed more severe clinical colitis than VDRf/f control mice, characterized by more robust T-helper (TH)1 and TH17 responses, with greater increases in mucosal interferon (IFN)-γ+, interleukin (IL)-17+, and IFN-γ+IL-17+ T cells. 29228157 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T<sub>reg</sub> cells through modification of the intestinal microbiota. 29915298 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE IL-17 A inhibition, IL-17RA inhibition and IL-17 knockout led to induction or exacerbation of colitis in mouse models. 28521565 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 AlteredExpression disease BEFREE Notably, in vivo inhibition of miR-425 significantly alleviated the disease severity of TNBS-induced colitis in mice, with down-regulated levels of IL-17A. 29331376 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 AlteredExpression disease BEFREE Increased levels of IL-17 and RORγt were also observed in this animal model of colitis with Hhcy. 29974377 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE Compared with the control group, TNBS‑treated mice had significantly higher secretion of IL‑17, higher DAI scores, a lower ratio of Treg, reduced colon lengths and higher histological scores for colon inflammation. 29620246 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE We blocked the IL-17A of the mouse model of TNBS-induced experimental intestinal colitis and fibrosis to further verify the potential inductive effect of IL-17A on EMT in vivo. 30097894 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE These results indicate IL-17 plays a protective role in AIEC strain E. coli LF82 induced colitis by promoting IL-22 secretion. 29195141 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis. 29728642 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 AlteredExpression disease BEFREE SCFAs mix protected from AOM/DSS-induced colorectal cancer by improving colon inflammation and disease activity index score as well as suppressing the expression of proinflammatory cytokines including IL-6, TNF-α and IL-17. 29694938 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE Transcriptomic analysis reveals a controlling mechanism for NLRP3 and IL-17A in dextran sulfate sodium (DSS)-induced colitis. 30297787 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE In the absence of IFNγ, intestinal inflammation in CD4 T cell recipient mice was associated with enhanced IL17 responses; consequently, targeting IL17 signaling in IFNγ-deficient mice reduced T cell-mediated colitis. 29416538 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 AlteredExpression disease BEFREE Mice with conditional deletion of HDAC2 in CD4<sup>+</sup> T cells have elevated IL-17 expression and severe colitis. 30375383 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4<sup>+</sup> T cells. 28582593 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE Consistent with this, IL-17-induced inflammation is significantly reduced in <i>NDR1-</i>deficient mice, and NDR1 deficiency significantly protects mice from MOG-induced experimental autoimmune encephalomyelitis (EAE) and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis likely by its inhibition of IL-17-mediated signaling pathway. 28219902 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE IL23 responsive ILC have been implicated in the pathogenesis of colitis in several innate murine models through the production of IL17, IFNγ, and GM-CSF. 29081776 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.600 Biomarker disease BEFREE Therefore, our results demonstrated that consumption of HSD <i>per se</i> triggered a histologically detectable inflammation in the colon and also exacerbated chemically induced models of colitis in mice by a mechanism dependent on IL-17 production most likely by both ILC3 and Th17 cells. 29379505 2017