Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.550 | Biomarker | disease | BEFREE | The aims of this study are to enhance bioavailability and investigate their impact on nuclear p65 and HIF-1α for the first time in experimental colitis.Dextran sulphate sodium was used to induce colitis in mice and effect of either free CAPE/PIC or CAPE/PIC loaded albumin nanoparticles treatment was observed on disease development and levels of cellular p65 and HIF-1α.Our results indicate that albumin nano-encapsulation of CAPE/PIC not only enhances its anti-inflammatory potential but also potentiates its ability to effectively modulate inflammation related biomolecular pathways. | 30430451 | 2019 | ||||
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0.550 | Biomarker | disease | BEFREE | In conclusion, the present study demonstrated that EEN attenuated DSS‑ and TNBS‑induced colitis by inhibiting p65 activation via regulating the p38/MSK1 pathway, thus suggesting that EEN is effective in the treatment of colitis. | 29901086 | 2018 | ||||
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0.550 | AlteredExpression | disease | BEFREE | Using a SOCS2<sup>-/-</sup> mice model of colitis we show that SOCS2-deficiency is pro-inflammatory and negatively correlates with NDR1 and nuclear p65 levels. | 28216640 | 2017 | ||||
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0.550 | AlteredExpression | disease | BEFREE | The chitosan/pUNO-SIGIRR nanoparticles attenuated colonic tissue inflammation through the inhibition of TLR4/NF-κB overactivation by downregulating TLR4, MyD88 and NF-κB p65 expression in a mouse model of colitis. | 28153604 | 2017 | ||||
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0.550 | Biomarker | disease | CTD_human | The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat. | 23810507 | 2013 | ||||
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0.550 | Biomarker | disease | RGD | Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. | 18623154 | 2008 | ||||
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0.550 | Biomarker | disease | BEFREE | Local administration of p65 antisense phosphorothioate oligonucleotides abrogated clinical and histological signs of colitis and was more effective in treating TNBS-induced colitis than single or daily administration of glucocorticoids. | 8782457 | 1996 |