Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE Regulatory DCs in Galectin-3:Toll-like receptor-4:Kynurenine-dependent manner promoted the expansion of colon-infiltrated T regulatory cells (Tregs) and suppressed Th1 and Th17 cell-driven colon inflammation. 31336879 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE In addition, we found that the canonical signaling downstream of TLR4 was activated in 2,4,6-trinitrobenzene sulfate-induced colitis in the wild type but not in the TLR4-deficient mice. 30672380 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE TLR4 and NF-κB in the therapy group were positively correlated with TNF-α mRAN (<i>P</i> < 0.050).Conclusion: In conclusion, probiotic VSL#3 inhibits the expression of NF-κB and TNF-α in rats with colitis through TLR4-NF-κB signal pathway, so it is expected to be a first choice drug for the treatment of colitis. 31497551 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 AlteredExpression disease BEFREE These findings indicate that core fucose is essential for CD14-dependent TLR4 and TLR2 signalling in murine macrophage activity, leading to DSS-induced experimental colitis. 30445455 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE In the second experiment, there were three groups: i) Group A1, control C57BL/6 mice; ii) group B1, E. coli‑treated DSS‑induced colitis BD C57BL/6 mice; and iii) E. coli‑treated DSS‑induced colitis BD TLR4‑/‑ mice. 30664156 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE Although oral administration of IAP significantly attenuated the severity of colitis in both preventive and therapeutic models of WT mice, these protective effects were not significant in TLR4<sup>-/-</sup> mice. 29247612 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE The Anti-Inflammatory Effect and Intestinal Barrier Protection of HU210 Differentially Depend on TLR4 Signaling in Dextran Sulfate Sodium-Induced Murine Colitis. 27995407 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE In order to investigate the Toll-like receptor-2 (TLR2), TLR4, and interleukin 10 (IL-10) molecular signaling pathways involved in BF-mediated prevention of dextran sulfate sodium (DSS)-induced colitis. 28683149 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE Intervention of Isomaltodextrin Mitigates Intestinal Inflammation in a Dextran Sodium Sulfate-Induced Mouse Model of Colitis via Inhibition of Toll-like Receptor-4. 28102669 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE In conclusion, oral administration of ML attenuated colitis in mice by inhibiting the binding of LPS to TLR4 on immune cells and increasing the polarization of M1 macrophages to M2 macrophages. 28189973 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE Taken together, the results suggest that the TLR4-Blimp-1 axis promotes DSS induced experimental colitis through the down-regulation of NLRP12. 27105524 2016
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE We found that EPS specifically bind peritoneal macrophages, and because mice lacking MyD88 signaling in myeloid cells were not protected by EPS, we conclude that bacterial EPS prevent colitis in a TLR4-dependent manner that requires myeloid cells. 24740503 2014
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE In this study, we investigated the involvement of NO production in activation of the TLR4/NF-κB signaling pathway in mice with DSS-induced colitis. 24992835 2014
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 GeneticVariation disease BEFREE Readressing the role of Toll-like receptor-4 alleles in inflammatory bowel disease: colitis, smoking, and seroreactivity. 22918682 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 AlteredExpression disease BEFREE In human UC samples, TLR4 expression was upregulated in almost all colitis-associated cancer and progressively increased with grade of dysplasia. 21674704 2011
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease RGD In this study, we investigated the effects of curcumin on the expression of TLR-4 and MyD88, the upstream signaling pathway in experimental colitis induced in the Sprague-Dawley male rats by intra-rectal administration of trinitrobenzenesulfonic acid (TNBS). 19002562 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE The main aims of this study is to evaluate effects of intraperitoneal injection recombinant human TFF3 on the expression of tumour necrosis factor alpha (TNF-alpha), toll-like receptor 4(TLR4), and nuclear factor kappaB (NF-kappaB) in trinitrobenzene sulphonic acid (TNBS) induced colitis mice. 19238529 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE These data demonstrate that lack of IL-10 had a greater effect on C. jejuni induced colitis than other immune elements such as TLR4 (C3H/HeJ, C3Bir IL-10(-/-)), MHC H-2g7, diabetogenic genes, and CTLA-4 (NOD) and that host genetic background is in part responsible for disease phenotype. 18586081 2008
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE Because knowledge on shifts in the intestinal microflora during colitis is limited, we performed a global survey of the colon flora of C57BL/10 wild-type (wt), TLR2(-/-), TLR4(-/-), and TLR2/4(-/-) mice treated for seven days with 3.5% dextrane-sulfate-sodium (DSS). 17653282 2007
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 GeneticVariation disease BEFREE We recently showed that mice deficient in Toll-like receptor 4 (TLR4) or its adapter molecule MyD88 have increased signs of colitis compared with wild-type (WT) mice after dextran sodium sulfate (DSS)-induced injury. 16952555 2006
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE In conclusion, our data provide evidence that E. coli Nissle 1917 ameliorates experimental induced colitis in mice via TLR-2- and TLR-4-dependent pathways. 16790781 2006
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.300 Biomarker disease BEFREE Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. 16622187 2006