|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The most implicated gene is HLA-DRB1, with HLA-DRB1*03:01 the most associated risk allele in both Crohn's disease and ulcerative colitis.
|
31518029 |
2019 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Integrative analysis of TWAS and messenger RNA (mRNA) expression data detected several tissues related common genes for UC, such as HLA-DRB1 (P<sub>TWAS</sub> = 0.024; mRNA expression ratio = 1.700) and TAP2 in colon (P <sub>TWAS</sub> = 0.047; mRNA expression ratio = 2.170).
|
31009124 |
2019 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
In a case-control approach, HLA-DRB1*15:02 was associated with UC in never smokers (OR<sub>never smokers</sub> = 3.20, P<sub>never smokers</sub> = 7.88 × 10<sup>-23</sup> ) but not in current or former smokers (P<sub>current smokers</sub> = 0.72 and P<sub>former smokers</sub> = 0.33, respectively).
|
31038770 |
2019 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two HLA-DRB1 causal alleles are shared with adult onset UC, while at least 2 signals are unique to pediatric UC.
|
29562276 |
2018 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Data on perinuclear ANCA (pANCA) and HLA-DRB1 were available from 274 ulcerative colitis (UC) patients without known liver disease.
|
27558072 |
2017 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, 9 genes previously associated with IBD contained SNPs with significant evidence for replication (P < 1.6 × 10<sup>-6</sup>): ADCY3, CXCR6, HLA-DRB1 to HLA-DQA1 (genome-wide significance on conditioning), IL12B,PTGER4, and TNC for IBD; IL23R, PTGER4, and SNX20 (in strong linkage disequilibrium with NOD2) for CD; and KCNQ2 (near TNFRSF6B) for UC.
|
27693347 |
2017 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
This is the novel result that describes an association of HLA-DRB1*13 with UC and also shows the protective role of HLA-DRB1*04 against the disease in people of Kerman.
|
26546900 |
2015 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
CTD_human |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
|
23942620 |
2014 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the HLA-DRB1*08 and *13 may contribute to the clinical heterogeneity of UC between Uyghur and Han UC patients in China.
|
24597629 |
2014 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genomic DNAs were obtained from a cohort of n = 383 subjects recruited as part of an Ulcerative Colitis study and analyzed for HLA-DRB1.
|
23555798 |
2013 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In Han patients with UC (n = 53), HLA-DRB1 *03, *13 allele frequencies were lower than in healthy controls (n = 161), but not statistically significant, and HLA-DRB1*04*11*14 allele frequencies were higher than in healthy controls, but without statistical significance.
|
23674880 |
2013 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DRB1*1502 allele was significantly more frequent in the Indian UC cohort (29.2%) than controls (17.6%) (P = 0.04) and the allele was absent in the white European cohort.
|
24145928 |
2013 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results show a significant association of the homozygous HLA-DRB1*07 genotype with UC and CD and of several HLA DR/DQ alleles and haplotypes with the clinical phenotypes of these diseases in Tunisian patients.
|
22224635 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Haplotype-based analysis in the major histocompatibility complex region showed that HLA-Cw*1202-B*5201-DRB1*1502 haplotype was significantly associated with increased risk of UC compared with CD (P = 1.1 × 10⁻³³; OR = 6.58), accounting for most of the associations observed in the GWAS.
|
21699788 |
2011 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that HLA-DRB1 alleles were associated with the clinical course of disease and steroid dependence in UC patients.
|
19674023 |
2010 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
A combination association map of Japanese UC using our current and previous studies showed two equal peaks of association on HLA-DRB1 and HLA-B, indicating the possible existence of two casual variants in the HLA region inside and outside the 400 kb block found in UK.
|
19493234 |
2009 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The rare HLA-DRB1*0103 allele was found to associate with UC (P = 0.008), and the TNFRSF1A A36G variant was associated with familial UC (P = 0.007).
|
18338763 |
2008 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The allele frequency of HLA-DRB1*09 was significantly higher in patients with UC diagnosed at the age of 40 years or older than in those with UC diagnosed before the age of 40 years (OR=2.31, Pc=0.022).
|
18416774 |
2008 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
LHGDN |
The allele frequency of HLA-DRB1*09 was significantly higher in patients with UC diagnosed at the age of 40 years or older than in those with UC diagnosed before the age of 40 years (OR=2.31, Pc=0.022).
|
18416774 |
2008 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
No significant associations were found between any FCRL3 SNP and CD or UC, but the stratification in patients with UC by human leukocyte antigen (HLA) showed a significant increase in heterozygosity at the FCRL3 locus, especially -169 AG (AG vs AA+GG, P= 0.0027, odds ratio = 3.6, 95% confidence interval 1.4-2.9), when HLA-DRB1*0103 carrier patients were compared with HLA-DRB1*0103 noncarriers.
|
17389014 |
2007 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that BTNL2 does not contribute to the susceptibility to Japanese CD but is associated with Japanese UC because of the strong LD with HLA-DRB1*1502.
|
17610417 |
2007 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 alleles showed no strong association with UC, and no HLA-DRB1 alleles or genotypes were strongly associated with clinical subgroups of UC in Chinese patients.
|
16426241 |
2006 |